辛伐他汀联合胺碘酮治疗阵发性心房颤动临床研究

Clinical study of simvastatin combined with amiodarone in the treatment of paroxysmal atrial fibrillation

目的观察辛伐他汀联合胺碘酮对心房颤动转复后维持窦性心律的用法及临床效果。方法回顾性分析2008年8月至2012年10月收治的74例阵发性心房颤动患者的临床资料，心房颤动转复后随机分为对照组及观察组各47例，对照组患者给予胺碘酮治疗，观察组同时给予辛伐他汀。比较两组患者治疗前后c．反应蛋白（CRP）水平，治疗后6个月及1年内房颤复发例数及不良反应发生情况。结果用药6个月后观察组患者CRP水平明显低于对照组；治疗6个月、12个月后观察组患者窦性心律维持率分别为94．6％、89．2％，对照组分别为78．4％、70．3％，组间比较差异均有统计学意义（P〈0．05）。两组患者均无明显不良反应发生。结论辛伐他汀联合胺碘酮对心房颤动患者转复后维持窦性心律效果明显优于单用胺碘酮，临床应用安全、有效。

Objective To observe the usage and clinical effect of simvastatin combined with amiodarone to maintain sinus rhythm after the atrial fibrillation cardioversion. Methods The clinical da- ta of 74 patients with paroxysmal atrial fibrillation treated in the fifth people＇ s hospital of Yongcheng from August 2008 to October 2010 were retrospectively analyzed. After the atrial fibrillation cardioversion, the patients were randomly divided into control group and observation group, for each group with 47 cases. The patients in control group were treated with amiodarone, and the patients in observation group were treated with simvastatin and amiodarone. The CRP levels before therapy and after therapy, atrial fibrilla- tion recurrence cases and adverse effects within 6 moths and 1 year were compared. Results The CRP level in the observation group was obviously lower than that in control group after 6 months of medication. Six months and 12 months later, the sinus rhythm in the observation group was respectively 94. 6%, 89.2% ,that in the control group was respectively 78.4% ,70.3%, there were significant differences a- mong the groups （P 〈 0.05 ）. There were no adverse reactions. Conclusions The clinical effect of sim- vastatin combined with amiodarone on maintaining sinus rhythm after the atrial fibrillation cardioversion is obviously superior to amiodarone only, besides, the clinical application is secure and effective.