热化疗治疗非小细胞肺癌对IL-2、IL-6、IL-8、IL-10及TNF的影响

Effect of thermochemotherapy on levels of IL-2 ,IL-6 ,IL-8, IL-10 and TNF in non-small cell lung cancer

目的探讨热化疗治疗非小细胞肺癌（NSCLC）对白细胞介素．2（IL-2）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）及肿瘤坏死因子（TNF）的影响。方法回顾性分析大同大学附属医院2004年10月至2013年1月收治的134例NSCLC患者，进行热疗联合NP方案化疗（NVB＋DDP），并分别在治疗前、治疗3个周期后、治疗6个周期后、治疗结束后3个月对患者血清中IL-2、IL-6、IL-8、IL-10及TNF的变化进行监测。结果热化疗3个周期后，IL-2、TNF水平逐渐增高，明显高于治疗前；IL-6、IL．8和IL-0水平明显低于化疗前。热化疗6个周期后，血IL-6、IL-8、IL-10,IL-2和TNF都有所下降，其中IL-2、TNF浓度显著低于化疗3个周期后的水平。热化疗结束后3个月，血IL-6、IL-8、IL-10水平继续下降；而IL-2、TNF浓度逐渐增高，低于化疗3个周期后的水平，但高于治疗前水平。结论热化疗治疗NSCLC对IL-2、TNF水平有明显的增高作用，而对IL-6、IL-8、IL-10有降低作用。

Objective To investigate the effect of hot therapy on intedeukin-2 （IL-2）, interleu- kin-6 （ IL-6）, interlerukin-8 （ IL-8 ）, interleukin-10 （IL-10） and tumor necrosis factor （TNF） in non- small cell lung cancer（NSCLC）. Methods One hundred and thirty-four patients with NSCLC, admitted to our hospital from October 2004 to January 2013, received hot therapy and vinorelbine plus cisplatin （NP） chemotherapy. The IL-6, IL-8, IL-10 and TNF level before therapy, after 3 cycles, after 6 cycles and 3 months after chemotherapy were observed. Results IL-2 and TNF levels increased gradually after 3 cycles of hot therapy, and were significant higher than those before therapy. Compared to before thera- py, IL-6, IL-8 and IL-10 levels significantly decreased. IL-6, IL-8, IL-10, IL-2 and TNF levels all de- creased at 6 months after hot therapy. IL-2 and TNF levels were significant lowered than those of 3 cycles after chemotherapy. IL-6, IL-8 and IL-10 continued to decrease 3 months after the end of hot therapy, but the levels of IL-2, TNF increased gradually and were lower than the levels of 3 cycles after chemotherapy and were higher than the levels before therapy. Conclusions Hot therapy for NSCLC can significantly in- crease IL-2, TNF levels and decrease IL-6, IL-8, IL-10 levels.