肠道菌群与心血管疾病关系的研究

Research on relationship between intestinal flora and cardiovascular disease

目的通过对心血管疾病患者肠道菌群和正常人肠道茵群之间的比较，找出肠道菌群和心血管疾病的关系。方法选取30例心血管疾病患者，以15名健康正常人作为对照。通过培养基改良的方法对留取的粪便进行肠道茵群分析。结果心血管疾病组较正常组的肠道菌群的比例发生了明显的变化。与正常组相比，肠道的大肠杆菌、肠球菌、链球菌均升高（P〈0．05），且链球菌明显升高（P〈0．01）；双歧杆菌及乳酸杆菌明显减少（P〈O．01）；葡萄球菌、韦荣球菌无明显变化（P〉0．05）。结论心血管疾病组较正常组的肠道茵群的比例发生了明显的变化，提示肠道茵群的变化与心血管疾病的发生及发展机制有一定关系，可能是促进心血管疾病发生的原因之一。

Objective To identify the relationship between intestinal flora and cardiovascular disease by the comparison the intestinal flora between the normal and the patients with cardiovascular dis- ease. Methods Intestinal flora detection by cultures, compared 30 cardiovascular patients with 15 healthy persons. Results There were significant changes in intestinal flora between cardiovascular group and the normal group. It was showed that compared with the healthy group, Bacillus coli, enterococcus and Chain coccus were increased （P 〈 0.05 ）, Chain coccus increased significantly （P 〈 0.01 ） ; both Ba- cillus bifidus and Bacillus acidi lactici decreased significantly（ P 〈0.01 ） ; Staphylococci and Veillonella had no statisticall significant difference（P 〉0. 05）. Conclusions There were significant changes in in- testinal flora between cardiovascular group and the normal group, patients with cardiovascular disease have imbalance of intestinal microbiota, and it might be related to the changes of intestinal flora.