压力控制法在治疗肺内源性急性呼吸窘迫综合征临床观察及安全性评估

Clinical observation and safety of pressure control method in the treatment of pulmonary acute respiratory distress syndrome

目的 分析压力控制法在治疗肺内源性急性呼吸窘迫综合征的临床疗效及安全性.方法 选取2012.1~2013.1入住我院的52例肺内源性急性呼吸窘迫综合征患者为研究对象,随机分为呼吸末正压递增法治疗的对照组及压力控制法治疗的观察组各26例,比较两组患者接受治疗后的呼吸指标、血流动力学数值、治疗安全性等差异.结果 观察组患者治疗后氧合指数（192.75±23.75）、肺静态顺应性（49.42±9.64）明显高于对照组患者（P〈0.05）;心率及平均中心静脉压略低于对照组患者,平均动脉压略高于对照组患者,比较差异无显著性（P〉0.05）;不良反应发生率（7.69%）明显低于对照组患者（P〈0.05）.结论 压力控制法可以有效提高肺内源性急性呼吸窘迫综合征的治疗效果,且具有良好的安全性.

Objective To analyze the clinical efficacy and safety of pressure control method in the treatment of patients with ARDS. Methods 52 patients with ARDS were randomly divided into two groups. The group A was given positive end-expiratory pressure increased treatment, and the group B received pressure control method. The re- spiratory indexes, hemodynamies, and treatment security differences were compared between the two groups. Results After the treatment, the oxygenation index was 192.75 ±23.75, and the static lung compliance was 49.42 ±9. 64 in the nhservation group, which was significantly higher than that in the control group （ P 〈 0. 05 ）. Heart rate and mean central venous pressure were slightly h）wer in the observation group than in the control group, and the mean ar- terial pressure was slightly higher in the observation group than in Ihe control group （ P〉 0. 05 ）. The incidem：e of ad- verse reactions was 7.69% in the observation group, which was significantly higher than that in the control group （ P 〈 0. 05 ）. Conclusion The application of pressure control method can improve the curative effect in the treatment of patients with ARDS, with a high safety.