IL-13和VEGF在肺炎支原体肺炎伴喘息儿童血清中检测及意义

Expression and its significance of IL-13 and VEGF in serum of infants with mycoplasma pneumoniae pneumonia complicated with wheezing

目的观察白细胞介素13(IL-13)和血管内皮生长因子(VEGF)在小儿肺炎支原体肺炎伴喘息儿童血清中的表达。方法住院58例肺炎支原体肺炎患儿分为喘息症状(A组,30例)和无喘息症状(B组,28例)两组;对照组(C组,30例)为健康儿童。采用酶联免疫方法检测三组血清中IL-13和VEGF的浓度。结果肺炎支原体肺炎患儿血清IL-13、VEGF的水平高于正常对照组;肺炎支原体肺炎伴喘息患儿的IL-13、VEGF的水平(分别为214.61±67.2 ng/L;0.55±0.13 ng/ml)高于肺炎支原体肺炎不伴喘息组(分别为189.56±52.1 ng/L;0.42±0.16 ng/ml),差异均有显著性(P<0.01)。结论血清IL-13、VEGF浓度增高可能在小儿肺炎支原体肺炎导致喘息样发作中起重要作用。

Objective To observe the expression of interleukin-13 （IL-13 ） and vascular endothelial growth factor （VEGF） in serum of children with mycoplasma pneumoniae pneumonia complicated with wheezing. Methods 58 children with mycoplasma pneumoniae pneumonia were divided into the group A with wheezing （30 cases） and the group B without wheezing （28 cases）. 30 healthy children were enrolled as the control group. Their serum levels of IL-13 and VEGF were measured by ELISA. Results The serum levels of IL-13 and VEGF were significantly high- er in the MP pneumonia gruup than in the healthy control group （P 〈0. 01 ） , and the levels were obviously higher in the group A than in the group B （ P 〈 0. 01 ）. Conclusion The increase of IL-13 and VEGF expression may play important roles in the pathogenesis of MP pneumonia and wheezing attack in children.