不同剂量阿托伐他汀治疗急性脑梗死患者对血清炎症因子的影响

Influence of different doses of atorvastatin on serum inflammatory factors in patients with acute cerebral infarction

目的:观察不同剂量阿托伐他汀治疗急性脑梗死对于患者血清炎症因子的影响,以及其降脂作用对于颈动脉粥样硬化的逆转疗效。方法:选取本院神经内科90例住院治疗的急性脑梗死患者作为研究对象,按照随机对照原则分为A、B、C 3组,每组30例,A、B、C组在接受急性脑梗死常规治疗基础上再分别给予阿托伐他汀0、10、20mg/d治疗,观察并对比3组患者血脂、血清炎症因子水平及颈动脉粥样硬化指标。结果:B、C组治疗后血脂和血清炎症因子水平均低于治疗前,且C组低于B组,B、C组治疗后的颈动脉内膜中层厚度(IMT)和斑块面积均低于治疗前及A组治疗后,C组治疗后的IMT和斑块面积均低于B组治疗后,差异具有统计学意义(P<0.05)。结论:阿托伐他汀可以有效抑制血清炎症因子水平,降低血脂,并可有效逆转颈动脉粥硬化,且以20mg/d剂量效果更为显著。

Objective：To observe the influence of different doses of atorvastatin on serum inflammatory factors in patients with acute cerebral infarction.Methods：Ninety cases with acute cerebral infarction hospitalized in Department of Neurology were selected and randomly divided into group A,B,C,respectively.Based on conventional treatment,group A,B and C were also given atorvastatin 0,10,20mg/ d serum levels of inflammatory factors and carotid atherosclerosis index were observed and compared among the three groups.Results：After treatment,group B and C showed lower serum lipids and inflammatory factors indexes compared with that before treatment.IMT and plaque size of group B and C were significantly lower than that treatment before.Between group B and C,IMT and plaque size was smaller and serum lipids and inflammatory factors indexes lower in group C than that in group B.After treatment, IMT and plaque size of group B and C were significantly lower than that in group A.Conclusions：Atorvastatin can effectively suppresse serum inflammatory cytokine levels,decrease blood lipids,and reverse carotid atherosclerosis,especially at the dose of 20mg/d.