呼吸道病毒特异性IgM抗体检测在儿童ALRI诊断中的临床应用价值

Clinical value of the detection of respiratory virus specific IgM antibody in the diagnosis of ALRI in children

目的:探讨本地区急性下呼吸道感染(ALRI)的流行病学特点,并研究呼吸道病毒特异性免疫球蛋M(IgM)抗体检测在儿童ALRI诊断中的临床应用价值。方法:选择我院646例儿童ALRI为研究对象,回顾性分析呼吸道病毒特异性IgM抗体的检测情况。结果:646例ALRI患儿腺病毒(ADV)、呼吸道合胞病毒(RSV)、柯萨奇病毒(CBV)、甲型流感病毒(IFVA)、乙型流感病毒(IFVB)及副流感病毒1,2,3型(PIV1、PIV2、PIV3)检测单一病毒感染率46.0%,复合感染率11.8%,其中以RSV 20.0%、ADV 10.1%、PIV 38.8%、IFVA 8.5%感染率较高;4种主要病毒IgM抗体检测阳性率年龄分布以6个月～1岁(81.3%)、1～3岁(45.7%)较高;季节分布RSV、IFVA、PIV3以冬春季高发;在不同临床诊断中ADV引起的支气管炎较为多见,IFVA、PIV3以支气管炎、支气管肺炎多见。结论:呼吸道病毒特异性IgM抗体检测在儿童ALRI诊断中有重要的临床应用价值。

Objective：To explore the epidemiological features of acute lower respiratory tract infection（ALRI）in this area,and to study the clinical value of detection of respiratory virus specific IgM antibody in the diagnosis of ALRI in children.Methods：A total of 646children with ALRI were enrolled as study objects,and a retrospective analysis of detection of respiratory virus specific IgM antibody was conducted.Results：Among the 646cases of ALRL,prevalence of ADV,RSV,CBV,IFVA,IFVB and PIV1,PIV2,PIV3was 46.0%,prevalence of combined infection was 11.8%,of which the prevalence of RSV（20.0%）,ADV（10.1%）,PIV（38.8%）,IFVA（8.5%）were higher;positive rate of the four main virus IgM antibody distributed mainly among children aged 6M-1Y（81.3%）,1-3Y（45.7%）;prevalence of RSV,IFVA,PIV3were higher in Spring;ADV caused most bronchitis,while IFVA and PIV3mainly caused trachitis,bronchial pneumonia.Conclusion：Detection of respiratory virus specific IgM antibody is valuable in the diagnosis of children with ALRI.