摘要
镉是一种分布广泛的重金属污染物,随着工业废弃物的排放通过水、植物、食物等途径进入食物链,从而在人体内蓄积,成为一种具有潜在毒性的有毒物质。镉对生物体的多个系统和器官均有毒害作用,其中有近50%的镉蓄积在肾脏,尤其是肾近曲小管,从而导致肾脏损伤,引发慢性肾脏疾病。本文对镉致肾脏毒性的机制如活性氧堆积、线粒体及内质网应激、钙紊乱、细胞凋亡等进行了总结,并简要的概述了其肾毒性的防治办法。
Cadmium is an environmental pollutant which is causing increasing concern as thousands of tons are re- leased from manufacturing industrial sites （ in particular manufacture of cadmium - nickel batteries）, contamina- ting water, plants and foodstuffs and eventually entering the food chain. The heavy metal cadmium accumulates in kidney cells, particularly those of the proximal tubular epithelium, and the damage this causes is associated with development of chronic kidney disease. In this review, we discuss novel roles for reactive oxygen species （ROS） , mitochondria, endoplasmic reticulum, calpains, caspases and apoptosis as part of cadmium - induced nephrotox- icity, and the protection against cadmium- induced neohrotoxicitv.
出处
《宜春学院学报》
2013年第12期80-83,共4页
Journal of Yichun University
关键词
镉
肾毒性
氧化应激
凋亡
防治
Cadmium
Nephrotoxicity
ROS
Apoptosis
Protection
