从中药及天然药物中寻找肿瘤多药耐药逆转剂的研究进展

Multi-drug resistance reversal agents from natural medicine and their advances

癌症是导致人类死亡的重要原因之一,其中以化疗为主的综合治疗手段为当前癌症患者的主要治疗方式。在癌症患者化疗过程中,肿瘤细胞产生的多药耐药是导致化疗失败的主要原因之一,因此,寻找和开发肿瘤多药耐药逆转剂是当前医药科技工作者十分重视的工作。中药及天然药物具有资源丰富、毒副作用小、蕴含化学成分多样化等特点,是寻找肿瘤多药耐药逆转剂的重要来源。经过数年的研究,已经从中药及天然药物中发现了一些具有肿瘤多药耐药逆转活性的天然产物。本文综述了自2000年以来,从中药及天然药物中寻找肿瘤多药耐药逆转剂的研究进展。

Cancer has become the leading cause of death. Chemotherapy with comprehensive treatment is the main treatment for cancer patients. Multi-drug resistance （MDR） is one of the main obstacles limiting the efficacy of clinical chemotherapy treatment for tumors. Consequently, searching for highly effective and lowly toxic MDR reversal agents is an important work with regard to cancer drug development. Traditional Chinese medicines （TCM） and natural medicines, which have rich resouce, little drug side effects and varied chemical constituents are important sources for new MDR reversal agents. In this paper, the advances of MDR reversal agents from TCM and natural medicine since 2000 are reviewed.