靶向CD47的抗肿瘤抗体研究进展

Anti-tumor antibodies targeting CD47

CD47是个多能分子，在肿瘤细胞逃避免疫监视过程中扮演重要角色，阻断CD47信号通道能有效激发巨噬细胞对肿瘤细胞的吞噬作用，成为非常有前景的肿瘤免疫治疗新途径。靶向CD47的单克隆抗体已成为近年来研究的新热点，目前的实验进展顺利，有必要进行更详尽的研究，使其早日进入临床应用。

CD47 is a pluripotent molecule which plays a key role in the process of tumor immune escape. Blocking CD47 signal pathway can activate the macrophages to phagocytose tumor cells, which becomes a promising way for tumor immunotherapy. Monoclonal antibodies targeting CD47 have been the new focus dur- ing recent years. Present researches are carried out successfully, however it still needs more work before the clinical application of monoelonal antibodies targeting CD47.