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姜黄素抗肿瘤作用机制 被引量:7

Effect and mechanism of curcumin on antitumor
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摘要 姜黄素可通过外在的死亡受体途径来诱导人类软骨肉瘤细胞的凋亡,诱导细胞周期阻滞抑制人肺癌细胞的增殖,通过阻断肿瘤细胞的多种生长信号传导通路来抑制胆管癌细胞的增殖并诱导其凋亡,通过减少血管内皮生长因子的表达来抑制艾氏腹腔积液癌细胞形成实体肿瘤的血管形成,通过调节肿瘤细胞黏附分子的表达来抑制乳腺癌细胞的游动性和侵袭方,还可以通过调节多药耐药相关基因的表达来增加化疗药物对癌细胞的敏感性。姜黄素的应用为肿瘤治疗开辟了新的途径。 Curcumin can induce cell apoptosis in human chondrosarcoma cells through extrinsic death receptor pathway, inhibit proliferation of lung cancer cells by inducing cell cycle arrest, and can suppress pro- liferation and induce apoptosis in cholangioearcinoma cells through blocking multiple signaling pathways, sup- press the formation of tumor blood vessels by reducing the expression of vascular endothelial growth factor in Ehdich ascites cancer cells, inhibit breast cancer cell motility and invasiveness by regulating the expression of adhesion molecules and increase the sensitivity of chemotherapy drugs to cancer cells by regulating the expres- sion of multidrug resistance related genes. Curcumin has explored new approaches for the treatment of tumor.
出处 《国际肿瘤学杂志》 CAS 2013年第11期823-826,共4页 Journal of International Oncology
关键词 肿瘤 细胞凋亡 姜黄素 Neoplasmas Apoptosis Curcumin
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  • 1Thiyagarajian S, Thirumalai K, Nirmala S, et al. Effect of curcuumin on lung resistance-related protein(LRP) in retinoblastoma ceils. Curr Eye Res, 2009, 34(10):845-851.
  • 2Lee HP, Li TM, Tsao JY, et al. Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death pathway. Int Immuno- pharmacol, 2012,13 (2) : 163-169.
  • 3胡辉,荆绪斌,蔡先彬,王钦加.姜黄素氧化损伤线粒体诱导肝癌SMMC-7721细胞凋亡的研究[J].重庆医学,2012,41(3):269-270. 被引量:6
  • 4Reinhardt HC, Schumacher B. The p53 network : cellular and system- ic DNA damage responses in aging and cancer. Trends Genet, 2012, 28(3) :128-136.
  • 5Penfield JD, Anderson M, Lutzke L, et al. The role of cellular senes- cence in the gastrointestinal mucosa. Gut Liver, 2013,7 ( 3 ) : 270- 277.
  • 6Bieging KT, Attardi LD. Deconstructing p53 transcriptional networks in tumor suppression. Trends Cell Biol, 2012,22(2) : 97-106.
  • 7蒋金,曹友德,磨娜,李静,莫显刚.姜黄素通过P53/P21/PCNA/eIF4E信号通路抑制A549细胞增殖[J].第三军医大学学报,2012,34(1):49-53. 被引量:13
  • 8Prakobwong S, Gupta SC, Kim JH, et al. Curcumin suppresses pro- liferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. Carcinogenesis, 2011,32(9) : 1372-1380.
  • 9Duarte VM, Han E, Veena MS, et al. Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of [KK-13 protein of the NF-KB pathway. Mol Cancer Ther, 2010,9(10) :2665-2675.
  • 10Tsai KD, Lin JC, Yang SM, et al. Curcumin protects against UVB- induced skin cancers in SKH-1 hairless mouse: analysis of early molecular markers in carcinogenesis. Evid Based Complement Alter- nat Med, 2012,2012: 593952.

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同被引文献108

  • 1王晓庆,梁中琴,顾振纶,范盘生.姜黄素抑制血管生成作用的实验研究[J].苏州大学学报(医学版),2004,24(3):277-279. 被引量:10
  • 2郑伟,杨向红,吴丽娜,韩豫生(校对).姜黄素抗血管生成分子机制的探讨[J].中国肿瘤临床,2007,34(12):683-685. 被引量:20
  • 3MALIK B, NIE D. Cancer stem cells and resistance to chemo and radio therapy[J]. Front Biosci ( Elite Ed), 2012, 4:2142 - 2149.
  • 4ZHOU BB, ZHANG H, DAMELIN M, et al. Tumour-initiating cells: challenges and opportunities for anticancer drug discovery [ J ]. Nat Rev Drug Discov, 2009, 8 (lO) : 806 - 823.
  • 5HIRSCH HA, ILIOPOULOS D, TSICHLIS PN,et al. Metformin selectively targets cancer stem cells, and acts together with chem- otherapy to block tumor growth and prolong remission[ J]. Cancer Res, 2009, 69(19): 7507-7511.
  • 6BAO B, AZMI AS, ALl S,et al. Metformin may function as anti- cancer agent via targeting cancer stem cells : the potential biologi- cal significance of tumor-associated miRNAs in breast and pan- creatic cancers[J]. Ann Translat Med, 2014, 2(6) : 59.
  • 7DECENSI A, PUNTON! M, GANDINI S, et al. Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial [ J ]. Breast Cancer Res Treat, 2014, 148 ( 1 ) : 81 -90.
  • 8DUPOUY S, DOAN VK, WU Z,et al. Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice[ J]. Oncotarget, 2014, 5 ( 18 ) : 8235 - 8251.
  • 9SHAFIEE MN, MALIK DA, YUNOS RI,et al. The effect of Met- formin on endometrial tumor-regulatory genes and systemic meta- bolic parameters in polycystic ovarian syndrome-a proof-of-con- cept study [ J ]. Gynecol Endocrinol, 2014, 11 : 1 - 5.
  • 10SCHULER KM, RAMBALLY BS, DIFURIO MJ,et al. Antipro- liferative and metabolic effects of metformin in a preoperative win- dow clinical trial for endometrial cancer[ J]. Cancer Med, 2015,4 (2) :161 -173.

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