Y盒结合蛋白1与上皮-间质转化

Y-box-binding protein 1 and epithelial-mesenchymal transition

在上皮-间质转化（EMT）过程中，细胞间连接被破坏，细胞失去顶一底极性，获得抗凋亡能力及迁移、侵袭能力。Y盒结合蛋白1（YB-1）是冷休克蛋白超家族的一员，包含结构和功能高度保守的冷休克结构域。研究表明，YB-1可以通过调控EMT促进肿瘤的发生发展。在YB-1介导的EMT中，多种转录因子及信号通路发挥着重要作用。

In the process of epithelial-mesenchymal transition （EMT）, cell-cell adherence is disrup- ted, apico-basal polarity is lost, the ability of anti-apoptosis, migration and invasion is acquired. Y-box-binding protein 1 （ YB-1 ） is a member of the cold-shock protein superfamily, containing a structurally and functionally conserved cold shock domain. Studies indicate that YB-1 can promote the occurrence and development of tumors by regulating EMT. In the process of EMT mediated by YB-1, various transcription factors and signal pathways play important roles.