摘要
食管癌小鼠模型有三大类：化学致癌模型、异种移植瘤模型和遗传工程模型。化学致癌模型很好地模拟了人食管癌发生发展的病理过程，制备方法简单；异种移植瘤模型是目前最常用的食管癌动物模型，具有成瘤快、成瘤率高、成本低的优点；遗传工程模型涉及的基因主要有p53、Cyclin D1、Brcal和p120ctn，有助于了解肿瘤的生物学特征，但其价格昂贵且制备时间长。
The esophageal cancer mouse models have three categories： chemical carcinogenesis model, xenograft tumor model and genetic engineering model. Chemical carcinogenesis model can simulate well the pathological processes of human esophageal cancer and is prepared simply. Xenograft tumor model is currently the most commonly used esophageal cancer animal model, which has advantages of rapid tumor formation, high- er tumor formation rate and lower cost. Genetic engineering model involves mainly p53, Cyclin D1, Brcal and pl20ctn, and it helps to understand the biological characteristics of tumors, but it is expensive and the prepara- tion time is long.
出处
《国际肿瘤学杂志》
CAS
2013年第12期915-918,共4页
Journal of International Oncology
基金
山东省科技发展计划项目（2012GGE27088）
关键词
食管肿瘤
小鼠
疾病模型
动物
遗传工程
Esophageal neoplasms
Mice
Disease models, animal
Genetic engineering
