两种内膜准备方案在多囊卵巢综合征患者冻融胚胎移植中的应用

Application of two endometrial preparation protocols in polycystic ovary syndrome patients for frozen-thawed embryo transfer

目的：探讨两种内膜准备方案在多囊卵巢综合征（PCOS）患者冻融胚胎移植中的应用价值。方法：回顾性分析了2011年10月～2012年10月在河北医科大学第二医院PCOS患者行冻融胚胎移植的95个周期，根据内膜准备方案分为：人工内膜组（56例），促排卵组（39例）。比较两组患者年龄、不孕年限、冷冻胚胎复苏率、优质胚胎率、平均移植胚胎个数、子宫内膜增殖时间、子宫内膜转化日血清雌二醇（E2）浓度、子宫内膜转化日子宫内膜厚度、胚胎种植率和临床妊娠率。结果：两组患者，人工内膜组子宫内膜转化13内膜较厚（11．61±1．59）mm，促排卯组内膜较薄（9．96±0．91）mm，但差异无统计学意义（P〉0．05）；两组间其他各项指标比较均无统计学差异。结论：PCOS患者冻融胚胎移植中使用来曲唑促排卯准备内膜可获得与人工内膜相似的结果，可根据患者的具体情况选择不同的内膜准备方案。

Objective： To investigate the application value of two endometrial preparation protocols in polycystic ovary syndrome （PCOS） patients in frozen -thawed embryo transfer （FET） cycles. Methods： PCOS patients of 95 FET cycles were analyzed. According to the endometrial preparation protocol, the patients were divided into two groups ： artificial endometrium group （56 cases）, ovulation induction group （39 cases） . Age, duration of infertility, recovery rate, high - quality embryo rate, the average number of embryos transferred, duration of the proliferation phase, the serum estradiol （E2） concentrations and endometrial thickness on the endometrial transformation day, embryo implantation and clinical pregnancy rates were compared between the patients of two groups. Results： In the artificial endometrium group, the endometrium was thicker than that of ovulation induction group, but there was no significant difference （ P 〉 0. 05 ） ; there was no statistical difference in the other indicators between the two groups. Conclusion： PCOS patients for frozen - thawed embryo transfer in letrozole ovulation induction and artificial endometrium cycles obtain similar results. The different endometrial preparation protocols can be chosen according to the specific circumstances of the patients.