宫颈上皮内瘤变及宫颈鳞癌中CD34与MK蛋白的临床价值

Clinical value of CD34 and MK protein in cervical intraepithelial neoplasia and cervical squamous cell

目的:探讨CD34与MK蛋白在宫颈上皮内瘤变(CIN)及宫颈鳞癌中的临床价值。方法:对医院妇科收治的30例CIN及40例宫颈癌患者的临床资料进行回顾性分析,取患者组织标本进行常规组织学处理,检测标本中CD34与MK蛋白的表达情况。结果:MK蛋白在CIN及宫颈鳞癌组织中的表达率分别为20.0%、57.5%,两组间比较差异有统计学意义(P<0.05),但是CIN分期间比较差异无统计学意义(P>0.05)。CD34在两种疾病中表达较高,两组比较差异有统计学意义(P<0.05),但是CIN分期间比较差异无统计学意义(P>0.05)。结论:CD34与MK蛋白在CIN及宫颈癌中高度表达,可用于指导治疗及判断预后具有十分重要的临床价值。

Objective： To investigate the clinical value of CD34 and MK protein in cervical intraepithelial neoplasia and cervical squamous cell carcinoma. Methods： 30 cases of gynecological cervical intraepithelial neoplasia and 40 eases of cervical cancer clinical data were retrospectively analyzed, tissue samples were taken for routine histological processing to test specimens of CD34 and MK protein expres- sions. Results： MK protein in cervical intraepithelial neoplasia and cervical squamous cell carcinoma were 20% , 57. 5% , the difference between the two groups was statistically significant （ P 〈 0.05 ）, but there was no significant difference among different cervical intraepithelial neoplasias period （ P 〉 0. 05 ） . CD34 expression in both diseases was higher, the difference was statistically significant （ P 〈 0. 05 ）, but there was no significant difference among different cervical intraepithelial neoplasias period （ P 〉 0. 05 ） . Conclusion： CD34 and MK protein in cervical intraepithelial neoplasia and cervical are highly expressed and can be used to guide treatment and prognosis, which has very important clinical value.