急性颅脑损伤患者血清NSE和S-100B水平的变化及临床意义

The Changes of NSE and s-100B Levels in Patients with Traumatic Brain Injury and its Clinical Significance

目的：探讨急性颅脑损伤患者血清NSE和S-100B水平变化在伤情判断及预后评估中的作用。方法：选择2010年5月-2012年5月2年间100例急性颅脑损伤患者（GCS≤12）分别于伤后4天、24天、72天、7天时测定NSE和S100的血清浓度，同时以同期体检中心就诊的患者（均无神经系统疾病史）30例作为对照组。颅脑损伤组患者随访6个月后进行GOS评分。结果：100例颅脑损伤患者血清NSE和S100B水平伤后均有升高，与对照组比较有显著性差异（P〈0．05）。预后不良组与恢复良好组之间比较，伤后血清NSE和S100水平均有升高，差异有显著性（P〈0．05）。结论：血清NSE和S-100B可以作为早期评估颅脑损伤患者病情及预后的一个有价值的指标。

Objective：To investigate the Changes of Serum NSE and s - 100B Levels in Patients with traumatic brain injury and its relation with the severity and Clinical outcome of TBI. Methods： One -hundred patients suffering from TBI （Glasgow coma score ≤ 12） were included, and 30 healthy volunteers were recruited as control in the study. Serum levels of NSE and s - 100B protein were measured by electrochemiluminescence immunoassay. All patients of the experimental group have Glasgow outcome scale after 6 months. Results： In traumatic brain injury patients ,the NSE and s -100B levels in serum increased significantly, and the difference was significant compared with the control （ P 〈 0.05 ）. Two groups according to Glasgow outcome scale, the higher of NSE and s - 100B levels in serum, the prognosis was worse （ P 〈 0.05 ）. Conclusion： This human study indicates that Serum NSE and s - 100B levels may be used as promising markers for evaluating severity and prognosis of TBI, especially in the patients at earlier post - traumatic interval.