期刊文献+

西妥昔单抗联合FOLFORI方案初始治疗晚期结肠癌1例 被引量:1

下载PDF
导出
摘要 《2012中国肿瘤年报》显示目前我国肿瘤的发病率为285.91/10万,平均每分钟有6人被诊断出患有恶性肿瘤。结直肠癌居全国恶性肿瘤发病率的第三位,死亡率第四位,城市地区的结肠癌上升速度比较快。有15%~25%的结直肠癌患者同时伴有肝脏转移,其中80%~90%的患者初次评估时肝脏病灶无法手术切除。自20世纪末奥沙利铂、伊立替康等药物的出现后,晚期结直肠癌的治疗有效率明显提高,生存期明显延长,近年来靶向治疗的应用更是取得令人鼓舞的进展。
出处 《癌症进展》 2013年第6期596-598,共3页 Oncology Progress
  • 相关文献

参考文献14

  • 1Van Cutsem E,Nordlinger B,Adam R,et al.Towards a pan-European consensus on the treatment of patients with colorectal liver metastases[J].Eur J Cancer,2006,42(14):2212-2221.
  • 2Van Cutsem E,K(o)hne CH,Hitre E,et al.Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer[J].N Engl J Med,2009,360 (14):1408-1417.
  • 3Ooi A,Takehana T,Li X,et al.Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers:an immunohistochemical and fluorescent in situ hybridization study[J].Mod Pathol,2004,17 (8):895-904.
  • 4Hecht JR,Mitchell E,Neubauer MA,et al.Lack of correlation between epidermal growth factor receptor status and response to Panitumumab monotherapy in metastatic colorectal cancer[J].Clin Cancer Res,2010,16 (7):2205-2213.
  • 5Dahabreh I J,Terasawa T,Castaldi PJ,et al.Systematic review:Anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectalcancer[J].Ann Intern Med,2011,154 (1):37-49.
  • 6De Roock W,Jonker DJ,Di Nicolantonio F,et al.Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab[J].JAMA,2010,304 16):1812-1820.
  • 7Tejpar S,Celik I,Schlichting M,et al.Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab[J].J Clin Oncol,2012,30 (29):3570-3577.
  • 8Saltz LB,Meropol NJ,Loehrer PJ Sr,et al.Phase Ⅱ trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor[J].J Clin Oncol,2004,22 (7):1201-1208.
  • 9Jonker D J,O'Callaghan C J,Karapetis CS,et al.Cetuximab for the treatment of colorectal cancer[J].N Engl J Med,2007,357 (20):2040-2048.
  • 10Cunningham D,Humblet Y,Siena S,et al.Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer[J].N Engl J Med,2004,351 (4):337-345.

同被引文献16

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部