冠心病患者颈动脉粥样硬化程度与血尿酸水平的相关性研究

Correlation between carotid artery atherosclerosis and blood uric acid level in patients with coronary heart disease

目的通过对冠心病患者进行血尿酸水平测定和颈动脉超声多普勒检查,探讨颈动脉硬化程度与血尿酸水平之间的相关性。方法选取59例冠心病患者,测定其血尿酸水平,并采用超声多普勒检测颈动脉内膜中层厚度(IMT)及斑块情况,分析二者的关系。结果颈动脉内膜增厚组患者的血清尿酸浓度为(271.3±50.1)μmol/L,明显低于颈动脉斑块形成组的(315.2±48.3)μmol/L(P<0.05);颈动脉狭窄组的血尿酸最低浓度为(347.8±51.2)μmol/L,明显高于颈动脉斑块形成组的(315.2±48.3μmol/L)(P<0.05);颈动脉狭窄组(分轻、中、重共3组)的血尿酸浓度分别为(347.8±51.2)μmol/L,(392.4±49.3)μmol/L和(430.7±48.6)μmol/L,三者之间经比较差异均有统计学意义(P<0.05);冠心病患者颈动脉粥样硬化程度与血尿酸水平存在明显正相关(r=0.4623,P<0.05)。结论冠心病患者颈动脉粥样硬化程度与血尿酸水平间存在正相关,临床诊疗中应该予以重视。

Objective To explore the correlation between carotid atherosclerosis and serum uric acid level through the detection of serum uric acid levels and examination of carotid artery by Doppler ultrasound in patients with coronary artery disease. Methods Fifty - nine patients with coronary heart disease were included in the study. Blood uric acid level was measured, carotid intima - media thickness （IMT） and plaque were detected, and the relationship between the two was ana- lyzed. Results Serum uric acid level of carotid intimal thickening group was （271.3 ± 50.1） μmol/ L, significantly lower than the carotid plaque group （315.2 ± 48.3） μmol/L （P〈0.05）. Serum uric acid level of stenosis group was （347.8 ± 51.2）μmol/L, higher than the carotid plaque group （315.2μ48.3） μmol/L （P〈0.05）. In Carotid stenosis group, levels of serum uric acid in each group were （347.8 ± 51.2） μmol/L, （392.4 ± 49.3）μmol/L and 430.7 _± 48.6μmol/L. There were significant differences between the three groups （ P 〈 0.05）. There was positive correlation between CHD carotid atherosclerosis and serum uric acid level （ r = 0. 4623, P 〈 0.05）. Conclusion There is positive correlation between carotid artery atherosclerosis and the level of blood uric acid level in CHD patients, and we should take it seriously in clinical diagnosis and treatment.