核黄素磷酸钠治疗多西他赛化疗后口腔溃疡的疗效分析

Analysis of therapeutic effect of riboflavin sodium phosphate in the treatment of oral ulcers induced by docetaxel-based chemotherapy

目的观察核黄素磷酸钠治疗恶性肿瘤患者行多西他赛化疗后所致口腔溃疡的临床疗效。方法将120例以多西他赛为主要化疗药物行全身化疗的恶性肿瘤患者随机分为2组，每组60例。全身化疗前24h，2组均给予地塞米松，治疗组在此基础上给予核黄素磷酸钠静脉滴注至化疗结束，观察化疗后患者的摄食量、第6及第8天的白细胞计数、口腔溃疡程度及溃疡恢复时间。结果治疗组患者出现摄食量明显下降及拒食的比例显著低于对照组，差异有统计学意义；治疗组化疗后第6天白细胞计数Ⅰ、Ⅱ度比例显著高于对照组，但Ⅲ、Ⅳ度比例明显低于对照组，而2组化疗后第8天白细胞计数比较无显著差异；治疗组Ⅰ～Ⅳ度口腔溃疡发生率均有低于对照组的趋势，且溃疡愈合时间明显短于对照组，差异有统计学意义。结论核黄素磷酸钠治疗恶性肿瘤患者行多西他赛化疗后所致的口腔溃疡临床疗效确切，不仅可防止患者出现摄食量明显下降，还对骨髓抑制有一定保护作用。

Objective To investigate the clinical effect of riboflavin sodium phosphate in the treatment of oral ulcers induced by docetaxel - based chemotherapy in patients with malignant tu- mors. Methods One hundred and twenty patients with malignant tumors who received docetaxel- based systemic chemotherapy were randomly divided into two groups, 60 cases in each group. Dex- amethasone was given in both groups 24 h before systemic chemotherapy, while the patients in the treatment group were injected intravenously with riboflavin sodium phosphate to the end of chemotherapy based on the above treatment. The amount of intake, white blood cell count on days 6 and 8, degrees and recovery time of oral ulcers were observed in both groups after chemotherapy. Results The proportions of significantly decreased food intake and apastia in treatment group were distinctly lower than in the control group, with statistical significance. The proportions of while cell count at grades I and lI in the treatment group on day 6 after chemotherapy were higher but those at grades l]I and IV lower than in the control group notably. Compared with white cell counts in both groups on day 8 after chemotherapy, there was no significant difference. The incidence of oral ulcers at grades Ill and IV in the treatment group was slightly lower and their healed time evidently shorter than in the control group, with statistical significance. Conclusion Riboflavin sodium phos- phate is very effective in the treatment of oral ulcers induced by docetaxel - based chemotherapy in patients with malignant tumors. It can not only prevent the patients from experiencing significantly decreased food intake, but also has a certain protective effect on myelosuppression.