度罗西汀联合氟桂利嗪治疗偏头痛伴焦虑的疗效分析

Analysis of therapeutic effect of duloxetine combined with flunarizine for migraine complicated by anxiety

目的探讨度罗西汀联合氟桂利嗪治疗偏头痛伴焦虑的临床疗效。方法将60例偏头痛伴轻度以上焦虑症的患者随机分为2组,治疗组给予氟桂利嗪联合度罗西汀口服治疗,对照组给予氟桂利嗪口服治疗,治疗周期为8周。治疗前及治疗后2、4、6、8周以汉密尔顿焦虑量表(HAMA)评定2组患者焦虑程度,并比较头痛程度及发作次数。结果治疗后2、4、6、8周,治疗组头痛发作次数均较治疗前明显减少,而对照组在治疗后8周出现明显减少,且治疗后6、8周,治疗组头痛发作次数明显少于对照组;治疗组治疗后8周头痛减轻程度明显优于对照组,差异有统计学意义;治疗后6、8周,治疗组HAMA评分显著低于对照组,差异有统计学意义。结论度洛西汀联合氟桂利嗪能有效减少偏头痛患者的头痛发作次数,减轻头痛程度,改善焦虑症状,临床疗效确切,值得临床推广。

Objective To explore the clinical effect of duloxetine combined with flunarizine in treating patients with migrine complicated by anxiety. Methods Sixty patients with migrine ac- companied with anxiety were randomly divided into treatment group which was orally administered duloxetine combined with flunarizine and control group which was orally administered flunarizine. The treatment cycle was 8 weeks. Hamilton anxiety scale （HAM_A） was used to assess the anxiety degree of patients in groups before and 2, 4, 6 and 8 weeks after treatment, and migrine degrees and attacks were compared. Results 2, 4, 6 and 8 weeks after treatment, attacks of migrine in the treatment group obviously went down compared with treatment before, while that in the control group also evidently decreased 8 weeks after treatment, and attacks of migrine in the treatment group were markedly less than in the control group 6 and 8 weeks after treatment. Tthe relieved de- gree of migrine in the treatment group was obviously superior to the control group 8 weeks after treatment, with statistical significance. Besides, 6 and 8 weeks after treatment, HAMA scores in the treatment group were significantly lower than in control group, with statistical significance. Conclusion Duloxetine combined with flunarizine can effectively reduce the attacks of patients with migrine, relieve the degree of migrine and ameliorate anxiety symptom. Its therapeutic effect is pre- cise, being worthy of promotion.