TIPE2与IL-8在慢性阻塞性肺疾病中的表达及临床意义

The expression and clinical significance of the TIPE2 and IL-8 in chronic obstructive pulmonary disease

目的:探讨白细胞介素-8(IL-8)以及肿瘤坏死因子α诱导的蛋白8-2(TIPE2)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)中的表达以及临床意义。方法:选取2012-04～2013-04佳木斯大学附属第一医院就诊的56例COPD患者。其中急性加重期30例(A组),稳定期26例(B组)。B组经过治疗之后为C组。选取相同时间到我院行常规体检的30例患者为参照组(D组)。分别检测所有患者血清中IL-8和TIPE2数值并予以比较。结果:比较患者血清中IL-8和TIPE2的浓度,A组较B组高,B组较C组高。A、B、C组均较D组高,差异均有统计学意义(P<0.05)。结论:IL-8和TIPE2在慢性阻塞性肺疾病的病程中参与呼吸道炎症反应;在COPD患者中动态检测血清IL-8和TIPE2有助于观察病情以及分析治疗效果。

Objective：To study the expression and clinical significance of the interleukin-8（IL-8） and the protein induced by tumor necrosis factor alpha 8-2（TIPE2） in chronic obstructive pulmonary disease（COPD）.Method：We chose fifty six patients who are diagnosed with chronic obstructive pulmonary disease in our hospital from April 2012 to April 2013.Thirty patients in COPD acute exacerbation period were divided into group A.Twentysix patients in COPD stable period were divided into group B.Group C were composed by those in group B after treatment.Then we chose 30 patients who did regular checkup in our hospital during the same period of time as group D.We detected IL-8 and TIPE2 of all patients and the compare the results.Results：After we compared the consentration of IL-8 and TIPE2 in different groups,we found the concentration in group A was higher than that ingroup B; the concentration in group B was higher than that in group C; the figures in group A,group B and group C were higher than that in group D（P〈0.05）.The differences were statistically significant.Conclusion：IL-8 and TIPE2 participate the respiratory inflammation of the chronic obstructive pulmonary disease（COPD）.From patients with COPD,we can observe the patients＇ condition dynamically by detecting IL-8 and TIPE2 and analyze the efficiency of the treatment.