维生素D与初诊男性2型糖尿病患者并发血脂紊乱的关系研究

Study on the relationship between serum 25-hydroxyvitamin D and dyslipidemia in male patients with newly-diagnosed type 2 diabetes mellitus

目的 探讨初诊男性2型糖尿病患者血清25-羟维生素D[25（OH）D]水平及其与血脂水平的关系.方法 选取在医院内分泌科住院的105例初诊男性2型糖尿病患者,收集常规及生化指标检测,检测所有受试者血清25（OH）D水平.按照血清25（OH）D水平进行四分位法分组,对年龄、BMI、甲状旁腺激素（PTH）、糖化血红蛋白（HbA1c）、空腹血清葡萄糖（FBG）、血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、血清钙（Ca）进行比较,并进行相关性分析.结果 维生素D正常11例（10.47%）,25（OH）D＜20ng/ml者62例（59.05%）,20～30ng/ml者32例（30.48%）.有血脂异常者85例（80.95%）.Q1组TG和PTH水平均低于Q2、Q3、Q4组,HDL-C水平高于Q2、Q3、Q4组,差异有统计学意义（P〈0.05）.血清25（OH）D水平与PTH、BMI、腹围、TG呈负相关,与HDL-C与呈正相关.结论 初诊男性2型糖尿病患者维生素D缺乏普遍存在,维生素D缺乏及继发性甲状旁腺激素升高与糖尿病相关血脂异常密切相关.

Objective To explore the relationship of Serum 25-hydroxyvitamin D （25 （OH） D） and dyslipidemia in male patients with newly- diagnosed type 2 diabetes mellitus（T2DM）. Methods 105 cases of patients with newly-diagnosed type 2 diabetes mellitus were selected as the object of study, the routine and biochemical indexes of which were collected and detected. All the subjects were detected the serum level of D 25 （OH）. According to the level of 25 （OH）D, all subjects were divided into 4 groups. The data of age, BMI, parathyroid hormone （PTH）, glycosylated hemoglobin （HbA1 c）, fasting serum glucose （FBG）, serum total cholesterol （TC）, triglyceride （three TG）, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C） were compared and analyzed. Results Vitamin D was normal in 11 cases （ 10. 47 % ）, 25 （OH） D 〈 20ng/ml （ in 62 cases, accounted for 59.05 % ）, 20 ~ 30ng/ml （ in 32 cases, accounted for 30.48 % ）. The patients with dyslipidemia were in 85 cases（80.95% ）. The level of TG and PTH of Q1 group was lower than that of Q2, Q3 and Q4 group, and the level of HDL-C of Q1 group was higher than that of Q2, Q3 and Q4 group, and the differences were statistically significant （ P 〈 0.05 ）. The serum 25 （OH） D level was negatively related with PTH, BMI, waistline, and positively related with HDL-C. Conclusion Vitamin D deficiency is common, and vitamin D insufficiency and secondary hyperparathy- roidism are associated with dyslipidemia in male patients with newly-diagnosed T2DM.