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锰与帕金森病发病机制的相关研究 被引量:1

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摘要 帕金森病(Parkinson's disease,PD)是中老年最常见的中枢神经系统变性疾病,近几年对PD的病因及发病机制尚不完全清楚,可能与年龄老化、环境毒素、遗传因素、神经系统老化、细胞凋亡等因素密切相关.主要病变部位在脑纹状体和苍白球等处,以中脑黑质致密带多巴胺能(DA)神经元选择性变性缺失、残留黑质和蓝斑出现 Levy 小体为病理特征.其主要临床表现为:静止性震颤、肌强直、运动迟缓、姿势步态障碍.随着社会逐步进入老龄化,PD患者的人数日趋增加.国外近期的统计资料表明,PD发病率占总人数的0.1%~0.2%,其中55岁以上人口占1.4%[1],因此PD成为国内外研究的热点.
出处 《成都医学院学报》 CAS 2013年第6期720-723,共4页 Journal of Chengdu Medical College
基金 国家自然科学基金(NO:81160143) 新疆维吾尔自治区自然科学基金(NO:2009211A17)
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