环糊精包含络合反应的荧光法研究

Fluorimetric Study on the Inclusion Complex Reaction of Cyclodextrin with Phenols

主客体包含化合物或络合物属引人注目的研究课题。环糊精(简称CD)、冠醚及穴醚等是重要的主体分子。CD为D-吡喃葡萄糖单元以α-1,4-糖苷键结合取椅式构象的环状低聚糖,尤以含6、7、8单元的α-CD、β-CD、γ-CD具有实际价值。CD分子具有特殊的结构和功能:它们均为内部疏水而端口亲水的锥形空腔结构,能与许多化合物形成主客体包含络合物,亦可成为优良的酶模拟模型,故在医药、卫生、食品、分离、分析、合成等领域广泛应用。对此已采用极谱法、伏安法、电导法、荧光法等进行研究。

A new fluorimetric method is developed for a study on the reaction of the host-guest inclusion complexes of cyclodextrin with phenols. Dissociation constants(Kd) of the inclusion comlexes of some phenols with β-cyclodextrin are estimated based on the variation of the fluorescent intensity and the modified Harada's equations.