新甾醇——绿柱虫甾醇A的结构测定

Structure Determination of a Novel Sterol——Clavisterol A

从中国南海采集的绿柱虫软珊瑚中分离到一种具有环丙烷结构的支链的新甾醇——绿柱虫甾醇A(clavisterol A.).通过各种波谱分析,确定了其结构.

A novel marine C30-sterol clavisterol A with an interesting cyclopropane moiety side chain, was isolated from the Chinese soft coral Clavularia viridis collected from Xisha Islands in the South China Sea. The crude methanol-CHCl3(10:1) extract was chromatographed to obtain the crude clavis-terol A from the cyclohexane (9%) ethyl acetate eluting portion. Pure clavisterol A is a needle crystal, m.p. 158-160℃ (from acetone/p. ether), [A]D20-2.5(CHCl3, C, 0.0233), molecular formula C30H50O, (HRMS, M+ 426. 3862). From the IR, MS, NMR data and comparing the data with those of cholesterol and stoloniferone-d, the structure of clavisterol A was designed as 1.