1-苯基-3-(3'-吲哚基)-5-取代苯基-2-吡唑啉的合成及~1H NMR和MS中的取代基效应

The Synthesis of 1-Phenyl-3-(3 '-Indolyl)-5-Substituted Phenyl-2-Pyrazolines and Their Substituent Effects in 1H NMR, MS

J-(3’-吲哚基)-3-取代苯基-2-丙烯-1-酮与茉肼反应,合成了10种新的1-苯基-3-(3’-吲哚基)-5-取代苯基-2-吡唑啉衍生物,其结构通过各种波谱证实.讨论了此系列化合物~1H NMR和Ms中的取代基效应,得出取代基常数σ或σ^+与质子化学位移,碎片相对丰度之间存在着良好的线性关系.

10 new l-phenyl-3-(3'-indolyl)-5-substituted phenyl-2-pyrazolines were synthesized by the reactions of phenylhydrazine with 1-(3'-indolyl )-3-substituted phenyl-2-propen-l-ones. The structures of pyrazolines have been confirmed by their elementary analysis and spectral analysis. A good linear relationship between σH and σ,(σm)in 1H NMR or the lg(KR/KH) and σ(σ+) in MS was discussed.