阻塞性睡眠呼吸暂停综合征患者鼻阻力变化

The variation of nasal obstruction in patients with OSAS

目的探讨阻塞性睡眠呼吸暂停综合征（ＯＳＡＳ）患者鼻阻力的变化在睡眠呼吸暂停发病机制中的作用。方法对３０名正常人、３０例鼾症、６０例ＯＳＡＳ患者在进行多导睡眠监测的基础上，行鼻阻力检测。结果轻、中度ＯＳＡＳ组鼻阻力为（１．０６±４．２５）Ｐａｓ／ｍｌ，重度ＯＳＡＳ组鼻阻力为（２．２９±９．７４）Ｐａ·ｓ／ｍｌ，鼾症组鼻阻力为（０．７１±０．３１）Ｐａ·ｓ／ｍｌ，均明显高于正常对照组（０．４０± ０．１３）Ｐａ· ｓ／ｍｌ（Ｐ＜０．０１），鼻阻力与鼾声指数呈正相关（ｒ＝０．２５８，Ｐ＜０．０１），但鼻阻力与睡眠呼吸紊乱指数（ＡＨＩ）、醒觉次数、最低血氧均无相关关系。结论鼾症、ＯＳＡＳ患者鼻阻力增加，可能与ＯＳＡＳ的发病有关。

Objective To study the variation of nasal resistance and its possible relationship to obstructive sleep apnea. Methods The detection of nasal resistance and polysomnography were performed in 30 normal subjects,30 snoring patients and 60 patients with OSAS. Results The study reveal that nasal resistance of the patients with oSAS (1 .06 ± 4.25)Pa.s/ml, (2.29 ± 9.74)Pa. s/ml or snoring (0.71 ± 0.31)Pa.s/ml was higher than that of normal group (0.40 ± 0. 13)Pa. s/ml (P < 0.01). There was a positive correlation between nasal resistance and snoring index (r = 0.258, P < 0.01), but there was no correlation among AHI,waken intervals,and nasal resistance. Conclusion Nasal resistance increased in the patients with snoring or OSAS, it may be a factor related with OSAS.