原发性胃恶性淋巴瘤16例胃镜下特征及临床特点分析

Characteristics under the gastroscope and clinical characteristics of 16 patients with primary gastric malignant lymphoma

目的探讨原发性胃恶性淋巴瘤的临床特点及镜下特征，提高临床诊疗效果。方法回顾性分析2004年至2010年襄阳市第一人民医院收治的16例原发性胃恶性淋巴瘤患者胃镜下表现情况及临床资料。结果16例中I期4例，Ⅱ期5例，Ⅲ期5例，Ⅳ期2例。单纯手术治疗4例，单纯化疗2例，手术及术后化疗10例，采用CHOP方案5例，R—CHOP方案7例。1例死于术后并发症，15例出院，随访12～61个月．死亡5例，存活2年以上9例（56．3％），5年及以上4例（25．0％）。结论原发性胃恶性淋巴瘤术前诊断困难，胃镜组织活检病理检查为最有效的诊断方法，个体化治疗方案有助于提高患者5年生存率，改善预后。

Objective To invetigate the clinical characteristics and characteristics under the gastroscope of primary gastric malignant lymphoma, in order to enhance the clinical diagnosis and treatment effect. Methods The clinical data of 16 patients with primary gastric malignant lymphoma treated in our hospital from 2004 to 2010 were retrospectively analyzed. Results The 16 cases were divided into four periods, there were 4 cases in number I period, 5 cases in number II period, 5 cases in number III period, and 2 cases in number IV period. Four cases were treated with surgery only, 2 cases were treated with chemotherapy only, 10 cases were treated with chemotherapy after the surgery, 5 cases were treated with CHOP method and 7 cases were treated with R-CHOP method. One patient died of postoperative complications, 15 patients discharged from hospital, the follow-up visited was 12 to 61 months found, and 5 cases died, 9 cases（56. 3% ） survived for more than two years and 4 cases（25.0% ） survived for more than five years. Conclusions The preoperative diagnosis of the primary gastric malignant lymphoma is difficult, gastroscope biopsy pathological examination is the most effective diagnostic method and individualized treatment is contribute to enhance the patients＇ five-year survival rate and can improve the prognosis.