儿童矮小症67例病因和治疗分析

Etiology and treatment of 67 children with short stature

目的探讨儿童矮小症的病因与治疗特点，为临床诊断治疗提供参考依据。方法对67例儿童矮小症患儿的临床资料进行分析，并使用重组人生长激素（rh—GH）和其他相关治疗。结果67例矮小症儿童中，生长激素（GH）缺乏性矮小23例，特发性矮小21例，家族性矮小9例，体质性青春发育延迟4例，宫内发育迟缓3例，Turner综合征、甲状腺功能减退、21-三体综合征各2例，先天性软骨发育不良1例。rh—GH对生长激素缺乏症（GHD）疗效显著，对特发性矮小、家族性矮小、宫内发育迟缓效果满意，非GH缺乏甲状腺功能低下者予以甲状腺素片治疗，生长增速。结论矮小原因很多，及时发现病因，寻求最佳治疗手段非常重要。

Objective To study the etiological factors and treatment feature of children with short stature, and provide reference for clinical diagnosis and treatment. Methods The clinical data of 67 children with short stature were analyzed, and they respectively adopted reorganization human growth hormone （rhGH） and comprehensive treatment. Results Among the 67 cases of children with short stature, growth hormone deficiency（GHD） in 23 cases, idiopathic short stature in 21 cases, familial short stature in 9 cases, constitutional delay of growth and puberty in 4 cases, 3 cases for intrauterine growth retardation（IUGR） , 2 cases for Turner syndrome, 2 cases for hypothyroidism, 2 cases for Down＇ s syndrome, 1 case for Congenital cartilage dysplasia. Rh-GH was effective on treatment of GHD, ISS, familial short stature and IUGR was better. The same curative effect could be achieved in hypothyroidism and non-GHD cases after treatment with thyroid tablets. Conclusions According to the pathogeny, selecting correct treatments is the key to treat the short stature children.