微流控纸芯片的加工技术及其应用

Fabrication Techniques of Microfluidic Paper-Based Chips and Their Applications

微流控纸芯片是一种新兴的微流控分析技术平台,具有成本低、加工简易、使用和携带方便等优点,在临床诊断、食品质量控制和环境监测等应用领域具有很大的应用前景,近年来,引起广大科学工作者极大的兴趣。本文着重介绍目前文献相继报道的各种纸芯片加工技术,包括紫外光刻、蜡印、等离子体处理、喷墨打印、喷墨溶剂刻蚀、绘图、柔印和激光光刻等技术。此外,还介绍了微流控纸芯片分析中的检测方法及其应用。

Microfluidic paper-based chip analysis is a burgeoning microfluidic technique. It possesses great potentials for application in clinical diagnosis,food quality control as w ell as environmental monitoring due to its attractive features such as low-cost,easy-to-fabricate,easy-to-use and portable. Its importance and utility are w idely acknow ledged and extensive research has been conducted in the past several years. This paper mainly aims to review the developed techniques for fabrication of microfluidic paper-based chips, including UV photolithography,w ax printing,plasma treatment,ink printing,ink jet etching,plotting,screen printing, flexography printing and laser treatment,and so on. The detection methods for the microfluidic paper-based chip analysis and applications of microfluidic paper-based chips are also review ed.