芦笋汁抗突变作用的研究

Studies on the Antimutagenic Effect of Asparagus Juice

用微核(MN)试验、姐妹染色单体交换(SCE)及精子畸形试验探讨芦笋汁对环磷酰胺(CP)致突变作用的影响,结果表明,单纯芦笋汁对小鼠骨髓细胞MN、SCE及精子畸形无明显影响,但一定剂量芦笋汁可使CP诱发的MN率降低、SCE减少、精子畸形率下降、均有剂量-效应关系和统计学意义。

Micronucleus (MN) test,sister chromatid exchanges (SCE) and sperm malformation test were used to study the effects of asparagus juice on the mutagenic activity of cyclophosphamide (CP) .It was found that,asparagus juice itself showed no effect on the incidence of MN,SCE and sperm malformation,but asparagus juice reduced the incidence of MN (from 60.0‰to 50.3‰-26.6‰),SCE (from 29.22 times/cell to 26.40-13.37 times/cell) and sperm malformation (from61.0‰ to51.2‰-28.6‰)induced by CP respectively.The inhibitory effects showed a dose dependent relation,which was statistically significant.