尿毒症患者红细胞免疫功能的临床观察

THE CLINICAL INVESTIGATION OF THE RBC IMMUNITY FUNCTION IN UREMIC PATIENTS

目的了解尿毒症患者的红细胞免疫功能的改变及血液透析的影响．方法：按Ｓｉｅｇｅｌ建立的标准红细胞免疫粘附试验（ＲＣＩＡ）进行。结果：尿毒症组 ＲＢＣ—Ｃ３ｂＲＲ水平低于正常对照组（ｐ＜ ０．０１）． ＲＢＣ－ＩＣＲ水平高于正常对照组（Ｐ＜０．００１）。血液透析组ＲＢＣ—ＩＣＲ水平低于内科一般治疗组（Ｐ＜０．０５）。结论：尿毒症患者存在继发性红细胞免疫功能低下，系外周血循环免疫复合物（ＣＩＣ）升高所致。血液透析可提高红细胞免疫功能．清除血循环中的部分ＩＣ．但不能改变巳低下的红细胞免疫粘附功能。故促进红细胞免疫功能的药物仍需要进一步探讨。

Objective in order to explore uremic patients RBC immunity function change and the consequence of blood purification Methods The experiment was conduced by the lever of RCIA which was designed by siegel Rusults Compared with that in normal group RBC--C3 bRR in uremic group was obviously lower (P< 0. 01 ), RBC--ICR in uremic group was higher (P< 0. 001 ). RBC--ICR in blood purification group was lower than physician normal treatment group (p< 0. 05). Conclusions Uremic patients had acquired RBC immunity function reduction, as the CIC in the circulatory system increased. Blood purification could increase RBC immunity adhesion development factor, it could relief some CIC in the circulatory system. but it couldn' t change the reducible RBC immunity function. So the medicaments of improvement RBC immunity function need to study more.