不同疗程糖皮质激素治疗慢性阻塞性肺疾病急性加重期的疗效观察

Effect observation of different course of glucocorticoid in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的观察不同疗程糖皮质激素治疗慢性阻塞性肺疾病急性加重期的临床效果。方法将86例慢性阻塞性肺疾病急性加重期患者随机分为观察组和对照组各43例。2组均采用全身应用糖皮质激素治疗,观察组采用5d疗法,对照组采用14d疗法。观察2组临床疗效、血气分析、肺功能及不良反应情况。结果 2组临床疗效、血气指标、肺功能改善情况差异均无统计学意义(P>0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论糖皮质激素治疗慢性阻塞性肺疾病急性加重期效果显著,而5d短期疗法能有效减少患者的不良反应,值得临床推广应用。

Objective To observe the clinical efficacy of different course of glucocorticoid in the treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods 86 cases patients with acute exacerbation of chronic obstruc-tive pulmonary disease were randomly divided into observation group and control group, each of 43 cases. Both of 2 groups were given systemic corticosteroid therapy, observation group used 5 days therapy, and control group used 14 days therapy. Obseved the clinical efficacy,blood gas analysis, pulmonary function and adverse reactions of two groups. Results Clinical efficacy, blood gas analysis, pulmonary function of 2 groups had no significant difference （ P 〉 0.05 ） ; adverse reactions incidence rate of observed group was lower than that of control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion The effect of glucocorticoid treatment of acute exacerbation of chronic obstructive pulmonary disease is significant, and 5d short-term therapy can effectively reduce the adverse reactions in patients,worthy of clinical application.