对-(二甲氨基)苯基锗倍半氧化物的合成、结构及其对体外培养癌细胞的作用

Synthesis and Structure of p-Dimethylaminophenylgermanium Sesquioxide and Its Effect on the Mitotic Activity of Tumor Cell in Vitro

在常压下,由N,N′-二甲基苯胺和GeCl_4合成了对-(二甲氨基)苯基锗倍半氧化物,研究了它的红外光谱、光电子能谱及热分析性质,讨论了化合物的结构.用体外细胞培养法,观察了它对人乳腺癌细胞分裂的抑制作用。

Under atomospheric pressure, the p-dimethylaminophenylgermanium sesquioxide was prepared. The characters of IR, XPS and TG-DTA show that the synthetic compound is the para-monogermanium substitued product. The sesquioxide possesses a higher polymerization degree than Ge-132.In the cell culture of breast carcinoma in vitro, the mitotic activity of tumor cell was obviously inhibited when the concentration of the compound is over 1. 0 mmol.