氯喹药物在水/1,2-二氯乙烷界面上的传输机理研究

Studies on Transfer Mechanism of Chloroquine at the Aqueous 1,2-Dichloroethane Interface

用滴电解液电极(EDE)极谱法、电流环扫伏安法和计时电位法研究了水相中氯喹离子、有机相中非离子化氯喹及以缔合物形式存在的氯喹在水/1,2-二氯乙烷界面上的传输过程.探讨了水相pH、氯喹浓度、EDE速度和扫描速度对传输行为的影响.提出了相应的传输机理.

Transfer processes of chloroquine in aqueous phase, non-ionized chloroquine and chloro-quine existing as ion-pair complex with tetraphenylborate in organic phase across the aqueous 1,2-CH2C1CH2C1 interface were studied by polarography with the electrode of drop electrolyte (EDE), cyclic voltammetry with current scanning and chronopotentiometry, respectively. Their transfer mechanisms were proposed. The effect of pH of aqueous phase, the concentration of chloroquine and the flow-rate of EDE as well as the scanning rate on transfer behavior was discussed. The interfacial potential difference and Gibbs transfer energy were calculated as ΔDCEWφ=0. 06 V, ΔGuo,DCE→W= -11. 58 kJ/mol, respectively.