血清降钙素原和血常规测定对细菌性肺炎的指导意义

The Implications of Serum Procalcitonion (PCT) and Blood Normal (BR) Detection in Patients with Bacterial Pneumonia

目的探讨血清降钙素原(PCT)和血常规(BR)在细菌性肺炎诊断中的应用价值,旨在为细菌性肺炎的诊治提供理论参考。方法选取中南大学湘雅三医院2011年1月至11月在呼吸、急诊、ICU住院的细菌性肺炎患者64例,同期健康对照组32例,血清PCT采用Brahms快速半定量法(PCT-Q)测定,同期检测血常规。结果细菌性肺炎组中,PCT、白细胞计数对诊断的敏感性分别为78%和63%,特异性分别为97%和70%,细菌性肺炎组较健康对照组PCT水平显著增高,相比较有显著性差异(P<0.05)。细菌性肺炎组抗生素治疗前和好转后,血清PCT水平显著下降,相比较有显著性差异(P<0.05)。结论血清PCT的测定对细菌性肺炎有鉴别诊断价值,特别是可反应抗生素治疗效果,值得临床推广应用。

Objective To evaluate the implications of the detection of Serum Procalcitonion （PCT） and BR in patients with Bacterial Pneumonia,and provide theoretical reference for diagnosis and treatment of Bacterial Pneumonia. Methods 64 samples were collected from patients with Bacterial Pneumonia in respiratory department. ICU and emergency department from January to November 2011,and compared with 32 healthy people .PCT and BR were measured. The PCT level was determined by Brahms PCT-Q method. Results The sensitivities of PCT and BR were 78 %and 63 %,respectively with the sepcificities being 97 %and 70 %.The serum PCT levels of Bacterial Pneumonia group were higher than the healthy group, compared the difference was significant （P〈0.05）. The serum PCT levels of Bacterial Pneumonia group before using antibiotics were higher than that after effective therapy, compared the difference was significant （P〈0.05）. Conclusions The serum PCT has diagnostic value for the Bacterial Pneumonia, and it is a useful index to assess the clinical efficacy in patients using antibiotics. It is worthy of clinical application.