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CD117阴性胃肠道间质瘤KIT基因突变一例 被引量：2

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摘要 患者女,40岁.因上腹部不适半年,于2013年2月17日入院.体检：腹部平坦,未见胃肠型及蠕动波,全腹未触及包块,Murphy征阴性.肛门指诊未见明显异常.胃镜检查：贲门见一不规则肿物,大小约3.0 cm ×4.0 cm,近环周,表面多处破溃,质硬,易出血.胃体充血,胃内有少量半透明液体,诊断：贲门肿物,慢性胃炎-非萎缩性,病理回报：（贲门）黏膜慢性炎症伴急性活动、水肿,胃小凹增生,并见坏死,坏死下见肌肉样组织.
作者 田压 马洪喜 马小波 王海莹 段秀梅
机构地区 [
出处 《中华病理学杂志》 CAS CSCD 北大核心 2013年第12期837-838,共2页 Chinese Journal of Pathology
基金 吉林省科技发展计划项目（20120733） 长春市科技计划项目（12SF58）
关键词 胃肠道间质瘤 CD117 基因突变 阴性 KIT 上腹部不适 MURPHY征 胃镜检查
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Rubin BP. Gastrointestinal stromal tumours:an update[J].{H}HISTOPATHOLOGY,2006,(01):83-96.
  • 2Buleje S J,Yábar B A,Guevara-Fujita M. Molecular and genetic features of gastrointestinal stromal tumors (GIST)[J].{H}Revista de Gastroenterologia del Peru,2012,(04):394-399.
  • 3卓士超.191例胃肠间质瘤的病理与临床分析[J].齐齐哈尔医学院学报,2011,32(17):2774-2776. 被引量：3
  • 4Fatima N,Cohen C,Siddiqui MT. DOG1 utility in diagnosing gastrointestinal stromal tumors on fine-needle aspiration[J].{H}CANCER CYTOPATHOLOGY,2011,(03):202-208.
  • 5梁建芳,郑绘霞,肖虹,武丽娜,王宏坤.胃肠道间质瘤病理诊断新进展[J].世界华人消化杂志,2010,18(1):58-64. 被引量：27
  • 6Tan CB,Zhi W,Shahzad G. Gastrointestinal stromal tumors:a review of case reports,diagnosis,treatment,and future directions[J].ISRN Gastroenterol,2012.595968.
  • 7Antonescu C. Gastrointestinal stromal tumors[J].{H}Current Topics in Microbiology and Immunology,2012.41-57.
  • 8洪金玲,李健,李洁,沈琳.胃肠间质瘤甲磺酸伊马替尼治疗前后c—kit／PDGFRα基因型改变与舒尼替尼临床疗效的相关性[J].中华病理学杂志,2012,41(6):386-390. 被引量：6
  • 9Bamboat ZM,Dematteo RP. Updates on the management of gastrointestinal stromal tumors[J].{H}Surgical Oncology Clinics of North America,2012,(02):301-316.

二级参考文献40

  • 1梁建芳,郑绘霞,李宁,程彩霞,肖虹,王宏坤.胃肠道间质瘤中P16基因甲基化和P16蛋白表达的临床意义[J].中华胃肠外科杂志,2007,10(4):372-375. 被引量：8
  • 2Antonescu Csommer G,Sarran L,et al.Association of KIT exonmutations with nongastric primary site and aggressive behavior:KIT mutation analysis and clinical correlates 120 gastrointestinal stromal tumors[J].Clin Cancer Res,2003,9 (9):3 329-3 337.
  • 3Kioshita K,Isozaki K,Hirota S,et al.c-KIT genemutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tunlors[J].J Gastroneterol Hepatol,2003,18(2):147-151.
  • 4Rubin BP,Heinrich MC,Corless CL.Gastrointestinal stromal tumour[J].Lancet,2007,369(9574):1 731-1 741.
  • 5Florence D,Jean YB.Gastrointestinal stromal tumors:biology and treatment[J].Oncology,2003,65(3):187-197.
  • 6Carlson JW,Fletcher CD.Immunohistchemistry for-catenin in the differential diagnosis of spindle cell lesions analysis of a series and review of the literature[J].Histopathology,2007,51(4):509-514.
  • 7Sabah M,Leader M,Kay E,et al.The problem with KIT:clinical-implications and practical difficulties with CD117 immunostaining[J].Appl Immunohistochem Mol Morphol,2003,11(1):56-61.
  • 8Tzen CY,Wang JH,Huang YJ,et al.Incidence of gastrointestinal stromal tumor:aretrospective study basedon immunohistochemical and mutational analyses[J].DigDis Sci,2007,52(3):792-797.
  • 9Schubert ML,Moghimi R.Gastrointe stinal stromal tuomor (GIST)[J].Curr Treat Options Gastroenterol,2006,9 (2):181-188.
  • 10Meitlnen M,Ldsota J.Gastrointestinal stromal tumor difinition,clinical,histological,imnmnohistchemieat,and molecular genetic feature and differential diagnosis[J].VirehowsAreh,2001,438(1):1-12.

共引文献32

同被引文献18

  • 1Liang J, Wu YL, Chen BJ, et al. The C-kit receptor-mediated signal transduction and tumor-related diseases[ J]. Int J Biol Sci, 2013, 9(5) :435-443.
  • 2Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors [ J 1. Science, 1998, 279(5350) :577-580.
  • 3Michelucei A, Chiappetta C, Cacciotti J, et al. The KIT exon 11 stop codon mutation in gastrointestinal stromal tumors: what is the clinical meaning [J]. Gut Liver, 2013, 7( 1 ) :35-40.
  • 4Hirota S, Ohashi A, Nishida T, et al. Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors[J].Gastroenterology, 2003, 125 ( 3 ) :6604567.
  • 5Poveda A, del Muro XG, Lepez-Guerrero JA, et al. GEIS 2013 guidelines for gastrointestinal sarcomas ( GIST ) [ J ]. Cancer Chemother Pharmacol, 2014, 74(5):883-898.
  • 6Corless CL, Schroeder A, Griffith D, et al. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib [ J ]. J Clin Oncol, 2005, 23 ( 23 ) : 5357- 5364.
  • 7Daum O, Grossmann P, Vanecek T, et al. Diagnostic morphological features of PDGFRA-mutated gastrointestinal stromal tumors: molecular genetic and histologic analysis of 60 cases of gastric gastrointestinal stromal tumors [ J ]. Ann Diagn Pathol, 2007, 11(1) :27-33.
  • 8Corless CL. Gastrointestinal stmmal tumors: what do we know now? [J]. Mod Pathol, 2014, 27 Suppl 1 :S1-S16.
  • 9姜兴莲,杨红,李科,董丹丹,胥颖,李芳华.DOG-1在胃肠道间质瘤中的表达及其临床意义[J].中华病理学杂志,2011,40(5):315-318. 被引量：18
  • 10陈秀婵,黄仕辉.原发于卵巢恶性胃肠道外间质瘤1例及文献复习[J].当代医学,2011,17(33):30-31. 被引量：3

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中华病理学杂志
2013年 第12期

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