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TROP2与肿瘤的关系及其作为肿瘤治疗靶点的价值 被引量：1

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摘要 恶性肿瘤是全球最主要的死亡原因.据WHO统计,2008年全球死于癌症的人数为760万人,占全球所有死亡人数的13％[1].恶性肿瘤的早期诊断是提高患者长期生存率、甚至治愈的关键,探索有效的早期诊断和对患者预后判断的可靠指标显得非常重要.癌基因的过表达是导致恶性肿瘤发生、侵袭和转移的重要因素,针对癌基因表达进行检测对疾病的治疗效果判断和预后评估起着越来越重要的作用,而靶向治疗则有可能使患者获得生命的延长甚至治愈.TROP2（tumor-associated calcium signal transducers 2）是一种与恶性肿瘤发生、侵袭和转移有关的癌基因,本文对TROP2与恶性肿瘤的关系及其潜在的靶向治疗价值的研究进展进行综述.
作者 黄华艺
机构地区 广西壮族自治区人民医院检验科 DepartmentofSurgicalOncology
出处 《中华病理学杂志》 CAS CSCD 北大核心 2013年第12期860-863,共4页 Chinese Journal of Pathology
关键词 恶性肿瘤 治疗靶点 癌基因表达 侵袭和转移 早期诊断 死亡人数 肿瘤发生 靶向治疗
分类号 R730.2 [医药卫生—肿瘤]
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参考文献37

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二级参考文献14

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中华病理学杂志
2013年 第12期

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