培哚普利联合胺碘酮治疗阵发性心房颤动的Meta分析

A Meta-analysis of Perindopril Combined with Amiodarone in Patients with Paroxysmal Atrial Fibrillation

目的评价培哚普利联合胺碘酮与单独使用胺碘酮治疗阵发性心房颤动的疗效。方法计算机检索Embase、Medline、PubMed、CochraneCentralRegisterofControlledTrials（CENTRAL）、中国生物医学文献数据库、中国期刊全文数据库、万方数据库2001～2013年中关于培哚普利联合胺碘酮治疗阵发性心房颤动的随机对照研究，依据纳入、排除标准选择文献，对纳入文献中的参考文献进行筛检，对文献质量进行严格评价和资料提取，对符合质量标准的RCT采用ReviewManager5．0软件进行Meta分析。结果Meta分析显示，培哚普利联用胺碘酮后对心房颤动患者窦律维持的OR为2．54（95％CI：1．83～3．53，P=0．000），左心房内径比单纯胺碘酮组减少0．31（95％CI：0．07～0．56，P：0．010）。结论心房颤动患者联合服用培哚普利与胺碘酮可降低心房颤动发生率及复发率，并更好的维持窦律，同时，对延缓心房颤动患者左心房扩大及改善心功能均有一定作用。

Objective To compare the efficacy of combination use of perindopril and amiodarone with simply use of amiodarone for the paroxymal atrial fibrillation. Methods We used computer to search through the database including Embase, Medline, Pubmed, PUBMED, Cochrane Central Register of Controlled trial, CBMdisc, CNKI, and wanfangdata to collect the original papers focus on the treat- ment of paroxymal atrial fibrillation. Strictly according to the including criteria and excluding criteria, we conducted the meta - analysis on this topic. Results The OR of combination use of perindopril and amiodarone for paroxymal atrial fibrillation was 2.54（95% CI： 1.83 - 3.53 ,P = 0. 000）. The inner diameter of left atrium decrease 0.31cm（95% CI：0.07 - 0.56 ,P = 0. 010 ）. Conclusion Combination use of perindopril and amiodarone for paroxymal atrial fibrillation can reduce the frequency of attack. Meantime, it is valid to delay the left at- rial enlargement and improve the cardic function.