糖尿病肾病患者糖化血红蛋白、超敏C-反应蛋白和尿微量白蛋白检测的临床意义

Clinical significance of HbA1c,hs-CRP and urine microalbumin detection in patients with diabetic nephropathy

目的探讨糖尿病肾病(DN)患者血糖化血红蛋白(HbA1c)、超敏C-反应蛋白(hs-CRP)和尿微量白蛋白(UmAlb)检测的临床价值。方法选择186例2型糖尿病(T2DM)患者,根据其24hUmAlb水平将患者分为三组:正常蛋白尿组(A组)79例,尿微量白蛋白组(B组)64例及临床蛋白尿组(C组)43例。另选取同期在我院做健康体检者60例作为对照组。分别采血及24h尿液检测HbA1c、hs-CRP及UmAlb水平并进行比较。结果 A、B、C三组患者HbA1c、hs-CRP及UmAlb水平均显著高于对照组(P<0.01);A、B、C三组间HbA1c、hs-CRP和UmAlb水平比较,差异均有统计学意义(A组<B组<C组,P<0.01)。结论 HbA1c、hs-CRP及UmAlb联合检测有助于DN的早期诊断,对评价患者病情及指导治疗有重要价值。

Abstract： Objective To evatuate tne v tein （hs--CRP） combined with urine microalbumin （UmAlb） in patients with diabetic nephropathy （DN）. Methods A total of 186 patients with type 2 diabetes meitus （T2DM） were divided into three groups accord-ing to their volume of 24--h UmAlb： normal albuminuria group（group A, n =79）, =64） and clinical albuminuria group（group C, n =43）. Sixty healthy people were The levels of HbAlc, hs--CRP and UmAlb were detected and compared among the The levels of HbAlc, hs--CRP and UmAlb in groups A, B and C were significantl UmAlb group（group B, n selected as control group. three groups. Results y higher than those in the control group （three P d0.01）. There were statistically significant differences among groups A, B, C in corn parison of levels of HbAlc, hs--CRP and UmAlb （group A%group B% group C, all P 〈0.01）. Detection of HbAlc, hs--CRP combined with UmAlb is helpful to early diagnosis of DN, and has clinical value for evahlatin the severity and directing treatment_ Conclusion important