期刊文献+

40例绝经后妇女三阴性乳腺癌的临床特点及病理特征

下载PDF
导出
摘要 目的探讨绝经后妇女三阴性乳腺癌的临床特点及病理特征。方法回顾性分析我院诊治的40例绝经后三阴性乳腺癌病例的临床及病理资料,统计并分析其发病率、发病年龄、首次发病的临床症状、部位、肿物大小、组织学类型、组织学分级、淋巴结转移及血行转移情况、病理分期等。结果 40例绝经后三阴性乳腺癌占同期乳腺癌患者总数的8%,中位年龄58岁,其中以乳腺肿块为首发症状就诊者33例(占82.50%),发生于右乳腺者25例(占62.50%),位于外上象限者21例(占52.50%),淋巴结转移者26例(占65.00%),肿物直径>3cm者29例(占72.50%),其中浸润性导管癌33例(占82.50%),Ⅱ期及以上者32例(占80.00%)。术后中位随访47个月,其中14例患者出现了局部复发和转移(占35.00%),有9例患者死亡(22.50%)。结论绝经后三阴性乳腺癌发病率较低,病理组织学分级较高,易局部复发和淋巴结转移,预后较差。
作者 李伟忠
出处 《右江民族医学院学报》 2013年第6期812-813,共2页 Journal of Youjiang Medical University for Nationalities
  • 相关文献

参考文献10

  • 1Perou CM, Sorlie T, Eisen MB, et al. Molecular por- traits of human breast tumours [J]. Nature, 2000, 406 (6797) ..747-752.
  • 2Brady-West DC, McGrowder DA. Triple negative breast cancer., therapeutic and prognostic implications [J]. Asian Pac J Cancer Prev, 2011, 12 (8): 2139 - 2143.
  • 3de Ruijter TC, Veeck J, de Hoon JP, et al. Characteris- tics of triple-negative breast cancer[J]. J Cancer Res Clin Oncol, 2011, 137(2):183-192.
  • 4柴文英,马芸,钱锦贤,蒋爱梅,程若川.三阴性乳腺癌的临床特征和预后分析[J].肿瘤预防与治疗,2010,23(1):36-40. 被引量:3
  • 5Krishnamurthy S, Poornima R, Challa VR, et al. Triple negative breast cancer - our experience and review [J]. Indian J Surg Oncol, 2012, 3(1):12-16.
  • 6Diaz-Cruz ES, Cabrera MC, Nakles R, et al. BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer[J]. Breast Dis, 2010, 32 (1-2):85-97.
  • 7Stoppa-Lyonnet D, Ansquer Y, Dreyfus H, et al. Fa- milial invasive breast cancers: worse outcome related to BRCA1 mutations[J]. J Clin Oncol, 2000, 18(24):4053 -4059.
  • 8Joensuu H, Gligorov J. Adjuvant treatments for triple- negative breast cancers [J] Ann Oncol, 2012, 23 Suppl 6 : vi40- 45.
  • 9张晓兰,王水,郑琳.三阴性乳腺癌82例临床特征与预后分析[J].实用临床医药杂志,2012,16(15):142-144. 被引量:3
  • 10Mtiller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis [J] Nature, 2001, 410(6824) :50-56.

二级参考文献38

  • 1黄宗海,苏国强,毛乾国,王庆志,厉周,俞金龙,范应方.血管内皮生长因子与nm23-H_1基因在青年女性乳腺癌组织中的表达及其与预后之间的关系[J].第一军医大学学报,2004,24(12):1398-1401. 被引量:6
  • 2Perou CM,Softie T,Eisen MB.et al.Molecular portraits of human breast tumours[J].Nature,2000,406(6797):747-752.
  • 3Garey LA,Perou CM,Livasy CA.el al.Raee,breast cancer sub-types,and survival in the Carolina Breast Cancer Study[J].JA-MA,2006,295(21):2492-2502.
  • 4Sorlie T,Perou CM,Tibshirani R.et al,Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical impli-cations[J].Proc Natl Aead Sci USA,2001,98(19):10869-10874.
  • 5Clcator S,Heller W,Coombes RC.Triple-negative breast cancer:therapeutic options[J].Lancet Oncol,2007,8(3):235-244.
  • 6Rakha EA,E1-Rehim DA,Paish c,et al.Basal phenotype identifies a poor prognostic subgroup of breast cancer of clinical importance[J].Cancer,2006,42:3149-3156.
  • 7Langerod A,Zhou H,Borgan O,et al.TP53 mutatlon status and gene expression profiles are powerful prognostic markers of breast cancer[J].Breast Cancer Res,2007.9:R30.
  • 8Nielsen TO,Hsu FD,Jenson K,et al.Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma[J].Clin Cancer Bes,2004,10(16):5367-5374.
  • 9Bidard FC,Conforti R,Boulet T,et al.Does triple-negative pheno-type accurately indentify basal-like tumor?An immunohistochemical analysis based on 143"triple-negative"breast cancers[J].Ann On-col,2007,18(7):1285-1286.
  • 10Dent R,Trudeau M,Prichard KI,et al.Triple-negative Breast Canc-er:Clinical features and patterns of recurrence[J].Clin Cancer Res,2007,13(15):4429-4434.

共引文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部