活动期溃疡性结肠炎与蛋白质和脂质代谢的相关性分析

Correlation between Active Ulcerative Colitis and Protein,Lipid Metabolisms

背景：溃疡性结肠炎（UC）已成为我国常见的慢性消化系统疾病之一，尽早对疾病活动性和严重度作出准确评估，有助于及时、正确的治疗。目的：分析活动期UC患者蛋白质和脂质代谢指标与疾病活动性和严重度之间的关系。方法：收集2006年1月～2012年11月上海市普陀区中心医院97例活动期UC患者和100名正常对照者，检测总蛋白（TP）、白蛋白（ALB）、球蛋白（GLB）、总胆固醇（TC）、三酰甘油（TG）、载脂蛋白A（ApoA）、载脂蛋白B（ApoB）、脂蛋白a（LPa）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（CDL-C），并分析与疾病活动性、严重度的关系。结果：活动期UC患者BMI、TP、ALB和TC均显著低于正常对照组（P〈0．05）。与轻度活动期UC患者相比，重度和中度活动期UC患者ALB明显降低（P〈0．05），重度活动期TG明显降低（P〈0．05），中度活动期ApoA明显降低（P〈0．05）。相关性分析表明TP与ESR相关（P〈0．05），ALB与ESR、CRP、CAI评分和Baron评分相关（P〈0．05），TC与Baron评分相关（P〈0．05）。结论：活动期UC患者易出现蛋白质和脂质代谢紊乱，TP、ALB、TC与疾病活动性相关；ALB与疾病严重度有关，可作为UC疾病严重度评价的客观指标之一。

Background： Ulcerative colitis （UC） has become one of the commonly seen chronic digestive system diseases in China. Early assessment of activity and severity of UC is helpful for the appropriate treatment. Aims： To analyze the correlation between protein, lipid metabolisms and disease activity, severity in active UC patients. Methods： Ninety-seven UC patients and 100 normal controls from Jan. 2006 to Nov. 2012 at Shanghai Putuo District Central Hospital were enrolled. Total protein （TP）, albumin （ALB）, globulin （GLB）, total cholesterol （TC）, triglyceride （TG）, apolipoprotein A （ApoA） , apolipoprotein B （ ApoB ） , lipoprotein a （LPa） , high-density lipoprotein cholesterol （ HDL- C）, low-density lipoprotein cholesterol （CDL-C） were measured, and their correlations with ESR, CRP, CAI score and Baron score were analyzed. Results： BMI, TP, ALB and TC in active UC patients were significantly lower than those in controls （ P 〈 0.05 ）. Compared with mild active UC patients, ALB in severe and moderate active UC patients was significantly decreased （ P 〈 0.05 ） , TG in severe active UC patients and ApoA in moderate active UC patients were significantly decreased （ P 〈 0.05 ）. Correlation analysis showed that TP was correlated with ESR （ P 〈 0.05 ）, ALB was correlated with ESR, CRP, CAI score and Baron score （ P 〈 0.05 ） , TC was correlated with Baron score （ P 〈 0.05 ）. Conclusions： Disorder of protein and lipid metabolisms occur in active UC patients. TP, ALB and TC are associated with disease activity, ALB can be used as an evaluation indicator for the disease severity.