固有淋巴细胞分化与肠道菌群调节研究进展

Advances in Study on Differentiation of Innate Lymphoid Cells and its Interplay with Gut Microbiota Regulation

固有淋巴细胞(ILCs)既是固有免疫的效应细胞,又是获得性免疫的前体细胞,可根据其表达的转录因子和产生效应分子的类型分为不同亚群,包括T-bet+ILC(ILC1)、GATA3+ILC(ILC2)和RORγt+ILC(ILC3)。肠道菌群参与了ILCs的分化,同时ILCs可通过产生不同类型的细胞因子影响肠道菌群组成。本文就ILCs分化与肠道菌群调节之间的相互关系以及ILCs在肠道菌群失调相关疾病中的作用作一综述。

Innate lymphoid cells （ILCs） are recognized as effectors of innate immunity and precursor cells of adaptive immunity. They can be categorized into three subgroups based on expression of transcription factor and patterns of effeetor molecules produced, including T-bet~ ILC （ILC1）, GATA3~ ILC （ILC2） and ROR~/t~ ILC （IEC3）. Intestinal commensal bacterial community is implicated in the differentiation of ILCs, and ILCs may affect the composition of gut microbiota via the distinct cytokines produced. The reciprocal interactions between ILCs differentiation and gut microbiota regulation, as well as the role of ILCs in dysbaeteriosis-related diseases were reviewed in this article.