血清雌二醇及睾酮与高尿酸血症的相关性研究

Correlations of estradiol and testosterone in hyperuricemia patients

目的探讨血清雌二醇、睾酮与高尿酸血症（HUA）的关系及临床意义。方法临床病例对照研究。收集中日友好医院2012年的193名体检者标本，测量血压、身高、体重，调查生活习惯、完善性别、年龄、疾病史等临床资料，按照尿酸（ua）水平分为HUA组（n=90）和健康对照组（n=103）。检测血清雌二醇、睾酮、血糖、血脂、肌酐、体质量指数（BMI），统计方法用统计学软件包SPSS19．0处理。组间比较用方差分析，两两比较用t检验；相关性分析用Pearson检验。结果健康对照组雌二醇水平高于HuA组[82．2（55．6—108．8）pm01／L〉65．8（36．6～95．0）pm01／L，t=3．991，P〈0．05]；健康对照组血清uA水平低于HUA组[300．8（207．2～394．4）izmoL／L〈426．9（370．1—483．7）Izmol／L，t=5．302，P〈0．05]。血清uA含量与睾酮为负相关（r=-0．312，P〈0．01）。血清uA与雌二醇为负相关（r=-0．319，P〈0．01）。结论血清雌二醇水平与高尿酸血症密切相关，可作为高尿酸血症的检查指标。

Objective To evaluate the serum concentrations of estradiol and testosterone in hyperuricemia patients and possible correlations of the two factors and uric acid （UA） in hyperuricemia （HUA） patients. Methods This was a case control study. We involved 90 hyperuricemia patients, 103 healthy controls. Estradiol, testosterone, UA, serum glucose, lipid profile, creatinine and body mass index （BMI） were estimated in two groups. The statistical analysis of the data were performed using SPSS version 19. 0 software. The estradiol, testosterone, UA, serum glucose, lipid profile, serum creatinine and BMI levels between the two groups were compared using the Student＇s t-test. Pearson correlation test was used to assess the correlation between serum UA levels and these indexes. Results Serum levels of estradiol in healthy subjects and hyperuricemia patients were 82. 2 （55.6-108.8） pmoL/L, 65.8 （36. 6-95.0 ） pmol/L respectively ; the serum levels of UA were 300. 8 （ 207.2-394. 4 ） p^mol/L, 426.9 （ 370. 1-483.7 ） p^mo]./L, respectively. The levels of estradiol were higher in the healthy control group than those in the hyperuricemia group. There were significant differences of estradiol levels between these two groups （ P 〈 0. 05 ）. Estradiol was negatively correlated with UA（ r = - 0. 319, P 〈 0.01 ） , so was testosterone （ r = - 0. 312, P 〈 0. 01 ）. Conclusion The findings of the present study suggest that in hyperuricemia patients, there are associations between estradiol and UA and the levels of serum estradiol might be used as biomarkers in hypemricemia.