不同麻醉药物对全麻苏醒期患者躁动的影响

Effect of Different Anesthetics on Emergence Agitation after General Anesthesia

目的探讨不同麻醉药物对全麻苏醒期躁动(EA)的影响.方法将134例术后出现EA的患者随机分为A组(42例)、B组(45例)和C组(47例),术后分别采用帕瑞昔布40 mg、布托啡诺20μg/kg和曲马多1 mg/kg,静脉注射.比较各组治疗后躁动的改善程度、VAS评分及Ramsay镇静评分等.结果治疗后,A组、B组患者EA的程度显著低于C组(P<0.05);治疗后,3组VAS评分显著下降,Ramsay镇静评分显著升高(P<0.05),其中C组VAS评分显著高于A组、B组,B组Ramsay镇静评分显著高于A组、C组(P<0.05);治疗后,B组患者苏醒时间、PACU停留时间显著高于A组、C组(P<0.05).结论帕瑞昔布治疗EA安全有效,可有效改善全身麻醉后EA患者的躁动程度,提高术后的镇静效果,缩短PACU停留时间.

Objective To explore the influence of different anesthetics on emergence agitation （EA） after general anesthesia. Methods 134 EA patients after general anesthesia were randomly divided into three groups. Group A （n =42） , Group B （n =45） and Group C （n =47） was given intravenously parecoxib 40 mg, butorphanol 20 μ g/kg and tramadol 1 mg/kg, respectively. The improvement of agitation, VAS score and Ramsay score were compared and analyzed among the groups. Results After treatment, the degree of EA in Group A, Group B was significantly lower than that in Group C （P〈0.05） . VAS score in all the cases was reduced, and Ramsay score was increased compared with that before treatment （P 〈0.05） VAS score in Group C was significantly higher than that in Group A, Group B （P〈0.05） . Ramsay score in Group B was significantly higher than that in Group A, Group C （P〈0.05） . After treatment, awaking time and postanesthesia care unit （PACU） stay in Group B was significantly higher than that in Group A, Group C （P〈0.05） Conclusions Parecoxib is safe and effective for EA after general anesthesia, it can effectively improve the degree of EA, increase postoperative sedative effect, and shorten PACU stay.