弓形虫棒状体颈部蛋白及棒状体蛋白研究的新进展

New advances in studies of Toxoplasma gondii rhoptry neck proteins and rhoptry proteins

刚地弓形虫(Toxoplasma gondii)是一种专性细胞内寄生原虫。因其复杂的生活史和致病机理,目前尚无有效的专用药物进行治疗。近年来,关于抗弓形虫免疫及疫苗的研究逐步深入,棒状体颈部蛋白(RONs)及棒状体蛋白(ROPs)作为重要的抗弓形虫疫苗的候选抗原分子,广泛应用于新型抗弓形虫疫苗的研究中。本文总结了近几年来弓形虫棒状体颈部蛋白及棒状体蛋白的研究新进展,尤其是这些RONs及ROPs作为新型DNA疫苗分子研究的最新进展。

Toxoplasma gondii is an obligate intracellular parasitic protozoan. There is no effective specific drug for treatment of T. gondii infection due to its complex life cycle and pathogenesis. With the increasing interests in studies of anti- T. gondii immunity and vaccines in recent years, rhoptry neck proteins （RONs） and rhoptry proteins （ROPs）, as potentially important anti-T, gondii vaccine candidate antigen molecules, have been studied extensively for anti-T, gondii immunity and vaccines. This article summarizes new progresses in studies of RONs and ROPs of T. gondii in recent years, especially those regarding the potentiality of RONs and ROPs as novel DNA vaccine molecules.