急性大肠癌并肠梗阻的治疗方法及临床安全性分析

The Clinical Safety Analysis of Acute Treatment of Colorectal Cancer and Intestinal Obstruction

目的探讨急性大肠癌并肠梗阻的治疗方法及临床安全性。方法将100例急性大肠癌合并肠梗阻患者按照抽签方法随机均分为对照组与观察组,各为50例。对照组给予保守治疗,观察组在此基础上给予外科手术治疗。比较两组复发转移情况、5年生存率以及并发症发生情况。结果①对照组复发转移率为24.00%,显著高于观察组的12.00%(P<0.05);②对照组3年生存率与5年生存率分别为70.00%、58.00%,均显著小于观察组的84.00%、80.00%(P<0.05);③两组均会出现伤口感染、腹腔感染、吻合口漏及脑梗塞等不良并发症,对照组不良并发症发生率为16.00%,观察组为14.00%,两组不良并发症发生率相比,差异无统计学意义(P>0.05)。结论外科手术治疗急性大肠癌并肠梗阻效果显著,安全性较高,值得在临床上加以推广并应用。

Objective To investigate the acute treatment of colorectal cancer and intestinal obstruction and its clinical safety. Methods 100 cases of patients with colorectal cancer complicated by acute intestinal obstruction were randomly divided into con- trol group and observation group with 50 cases in each by drawing lots. The control group were given conservative treatment, and the observation group were given surgical treatment on the basis of conservative treatment. The incidence of recurrence and metastasis, five-year survival rate and the incidence of complications were compared between the two groups. Results （1）The rate of recurrence and metastasis of the control group was 24.00%, which was significantly higher than that （12.00%）of the observation group （P〈0.05）; （2） the 3-year survival rate and five-year survival rate of the control group was 70.00% and 58.00%, respectively, which were significantly lower than those（84.00%, 80.00%） of the observation group（P〈0.05）; （3）Wound infection, abdominal infection, anastomotic leakage, cerebral infarction and other undesirable complications occurred in both groups. The incidence of complications of the control group was 16.00%, and that of the observation group was 14.00%, and there was no statistical difference between the two groups （P〉0.05）. Conclusion The surgical treatraent for colorectal cancer and acute intestinal obstruction is quite effective and safe, which is deserved to be promoted and applied in clinical practice.