视黄醇结合蛋白4与妊娠期糖尿病的研究进展

Recent Advances in Retinol Binding Protein-4 and Gestational Diabetes Mellitus

视黄醇结合蛋白4(RBP4)是新近发现的脂肪因子,主要由肝脏和脂肪组织分泌,具有调节糖脂代谢的作用。RBP4与胰岛素抵抗(IR)、代谢综合征等密切相关。妊娠期糖尿病(GDM)是常见的妊娠合并症,发病率逐年上升,但其发病机制不甚明确,认为与IR和胰岛素分泌相对不足相关。近年来对RBP4及相关脂肪因子的研究发现,RBP4不仅是肥胖及糖尿病患者IR的关联因子,而且和其他脂肪因子一同与GDM的发病、产后发生2型糖尿病、代谢综合征及子代预后等密切相关,但对此结论仍存在争议。

Retinol binding protein-4 （RBP4） is a newly discovered adipocytokine mainly secreted by liver and fat cells, which can regulate glucose and lipid metabolism. RBP4 is closely related to insulin resistance and metabolic syndrome. Gestational diabetes mellitus （GDM） is a common pregnancy complications ,its incidence is increasing, but its pathogenesis is unclear,which is considered to be associated with insulin resistance,regardless of compensatory insulin secretion. Recent studies on adipokines including RBP4 have suggested that RBP4 is not only the association factor in obesity and diabetes mellitus and insulin resistance,but also the novel factor closely related to the pathogenesis,prognosis and risk of type-2 diabetes mellitus and metabolic syndrome in the women with previous GDM and offspring of GDM. However,RBP4 is still a controversial adipokine.