母体蜕膜微环境与滋养细胞浸润

Maternal Decidual Microenvironment and Trophoblast Cell Invasion

在正常妊娠过程中,胎盘滋养细胞具有类似肿瘤的浸润能力,但与肿瘤细胞不同的是,滋养细胞对母体子宫蜕膜的浸润受到机体的严格调控,是有节制的正常生理行为。滋养细胞侵入过度可以导致绒毛膜癌等滋养细胞疾病的发生,浸润不足则可造成流产、子痫前期等妊娠期疾病。目前,滋养细胞有节制浸润母体的机制尚不明确,研究表明母体蜕膜微环境对滋养细胞的浸润起着重要的调控作用,对其进行深入研究有助于理解病理性妊娠的发生、发展过程。

During normal pregnancy, placental trophoblast cells have the ability to invade-like tumor cells. However, unlike tumor invasion, trophoblast cell invasion to the maternal deciduas is under highly control and is a normal physiological behavior. The overinvasion and inadequate invasion can lead to such pathologies of pregnancy as choriocarcinoma,miscarriage and preeclampsia,respectively. Nowadays, the mechanisms responsible for trophoblast cell invasion to maternal deciduas remain unidentified. Evidence indicates that the maternal decidual microenvironment exerts important influence over trophoblast cell invasion. The further study will be helpful to understand the pathogenesis of pathological pregnancy.