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TLR3在宫颈抗病毒免疫及宫颈病变中的作用 被引量：3

Role of TLR3 in Cervical Antiviral Immunity and Cervical Lesions
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摘要 Toll样受体3(toll-like receptor 3,TLR3)是天然免疫中重要的模式识别受体(PRRs)家族成员之一,可以特异性地识别病毒双链RNA,激活宿主保护性免疫反应,清除病毒。TLR3主要表达于免疫细胞,也可在上皮细胞及上皮细胞来源的肿瘤细胞中表达,在机体抗感染、炎症反应、肿瘤进展等病理生理过程中发挥重要作用。女性生殖道黏膜是抵抗病原微生物感染的重要屏障,TLR3参与女性生殖道生理、病理改变。对TLR3在宫颈人乳头瘤病毒(HPV)持续性感染、宫颈癌前病变及宫颈癌发生中的作用进行综述。 Toll-like receptor 3 （TLR3） is an important member of the family of pattern recognition receptors （PRRs） in innate immunity and can be specific to identify the virus double-stranded RNA,activate the protective response and clean viruses. TLR3 expresses mainly in immune ceils and also in epithelial cells and epithelial carcinomas. TLR3 expression is associated with infection, inflammation and tumor progression. Female genital tract mucous membrane is an important barrier against pathogenic microorganism infection,TLR3 expression is associated with genital tract physiology and pathology. The review will discuss the role of TLR3 in cervical HPV persistent infection, intraepithelial neoplasia and cervical cancer.
作者 瞿全新 糜若然
机构地区 天津市第一中心医院妇产科 天津医科大学总医院妇产科
出处 《国际妇产科学杂志》 CAS 2013年第6期545-547,共3页 Journal of International Obstetrics and Gynecology
关键词 癌前状态 宫颈肿瘤 TOLL样受体3 乳头状瘤病毒科 乳头状瘤病毒疫苗 Precancerous conditions Uterine cervical neoplasms Toll-like receptor 3 Papillomaviridae Papillomavirusvaccines
分类号 R737.33 [医药卫生—肿瘤]
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参考文献19

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同被引文献22

  • 1曾治民,何静,刘安文.Toll样受体信号传导与炎症相关肿瘤的关系[J].中国癌症杂志,2011,21(6):489-494. 被引量：17
  • 2Liu Y, Yan W, Tohme S, et al. Hypoxia induced HMGBI and mitochondrial DNA interactions mediate tumor growth in hepato- cellular carcinoma through Toll-like receptor 9 [ J]. Hepatol, 2015,63(1) :114-121.
  • 3Kauppila JH, Korvala J, Manni M, et al. Toll-like receptor 9 mediates invasion and predicts prognosis in squamous ceil carci- noma of the mobile tongue [ J ]. Oral Pathol Med, 2015, 44 (8) : 571-577.
  • 4Jouhi L, Koljonen V, Haglund C, et al. The expression of' Toll- like receptors 2, 4, 5, 7 and 9 in Merkel cell carcinoma[ J]. An- ticancer Res, 2015, 35(4) :1843-1849.
  • 5Weidner N, Joseph P, William R, et al. Tumor angiogenesis and metatasis correlation in invasive breast carcinoma[ J ] .New Engl J Med, 1991, 324(1): 1-8.
  • 6Luo Y, Jiang QW, Wu JY, et al. Regulation of migration and in- vasion by Toll-like receptor-9 signaling network in prostate cancer [ J ]. Oncotarget, 2015, 6 (26) : 22564- 22574.
  • 7Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer[J]. Celt, 2010, 140(6) :883-899.
  • 8Moreira D, Zhang Q, Hossain DM, et at. TLR9 signaling through NF-KB/RELA and STAT3 pmotes tumor-propagating potential of prostate cancer cells [ J ]. Oncotarget, 2015, 6 ( 19 ) : 17302 -17313.
  • 9Wan GX, Cao YW, Li WQ, et al. Associations between TLR9 polymorphisms and cancer risk: evidence from an updated meta- analysis of 25,685 subjects[ J ]. Asian Pac J Cancer Plv, 2014, 15(19) :8279-8285.
  • 10毕秋英,张栋,瞿全新.调节TLR3/PI3K信号转导通路抑制宫颈癌细胞生长的体外研究[J].现代妇产科进展,2012,21(1):31-34. 被引量：5

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国际妇产科学杂志
2013年 第6期

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